Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOX4 | Q9NPH5 | 2/20 | 0.59 |
| ▸ | PLG | P00747 | 1/20 | 0.59 |
| ▸ | AKR1B1 | P15121 | 3/20 | 0.57 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.56 |
| ▸ | POLH | Q9Y253 | 6/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.54 |
| ▸ | MEN1 | O00255 | 5/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.54 |
| ▸ | MAPT | P10636 | 4/20 | 0.54 |
| ▸ | RECQL | P46063 | 4/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.54 |
| ▸ | POLB | P06746 | 4/20 | 0.54 |
| ▸ | GAA | P10253 | 4/20 | 0.54 |
| ▸ | MMP1 | P03956 | 2/20 | 0.54 |
| ▸ | APEX1 | P27695 | 2/20 | 0.54 |
| ▸ | BLM | P54132 | 2/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 3/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.52 |
| ▸ | APP | P05067 | 2/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3404530 | 0.94 | AKR1B1 (0.64) | NOX4PLGAKR1B1EPHX2POLH | |
| SCHEMBL3985496 | 0.91 | MEN1 (0.64) | NOX4PLGAKR1B1EPHX2POLH | |
| SCHEMBL31287228 | 0.89 | EPHX2 (0.63) | NOX4AKR1B1EPHX2POLHKDM4E | |
| SCHEMBL5090723 | 0.89 | AKR1B1 (0.59) | NOX4AKR1B1EPHX2POLHKDM4E | |
| SCHEMBL8442485 | 0.86 | POLH (0.64) | NOX4PLGAKR1B1EPHX2POLH | |
| SCHEMBL17938761 | 0.79 | CYP3A4 (0.61) | AKR1B1EPHX2POLHKDM4EMEN1 | |
| SCHEMBL13846134 | 0.78 | POLH (0.58) | NOX4PLGAKR1B1EPHX2POLH | |
| SCHEMBL9958094 | 0.78 | PTGES (0.51) | NOX4PLGAKR1B1KDM4EMEN1 | |
| SCHEMBL9958617 | 0.77 | ABCG2 (0.51) | NOX4PLGEPHX2ABCG2ABCB1 | |
| SCHEMBL13846136 | 0.76 | POLH (0.66) | NOX4AKR1B1EPHX2POLHKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009064485-A1 | ANTIOXIDANT FLAVONOID DERIVATIVES | TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2009-05-22 | — | — | WO | disclosed |