Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR4A2 | P43354 | 6/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.34 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.34 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.33 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.33 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.33 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.33 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.33 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.33 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.33 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.33 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.33 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.32 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.32 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3989840 | 0.94 | MTNR1A (0.39) | NR4A2MTNR1AMTNR1BABCG2 | |
| SCHEMBL3995936 | 0.89 | ALDH1A1 (0.44) | ALDH1A1HDAC1HDAC2HDAC6HDAC3 | |
| SCHEMBL3986985 | 0.83 | ABCG2 (0.47) | NR4A2ALDH1A1MTNR1AMTNR1BLMNA | |
| SCHEMBL3992240 | 0.82 | POLB (0.38) | NR4A2ALDH1A1POLBLMNACNR2 | |
| SCHEMBL3992947 | 0.82 | POLB (0.38) | ALDH1A1POLBLMNACNR2MEN1 | |
| SCHEMBL3997478 | 0.80 | POLB (0.36) | NR4A2ALDH1A1POLBLMNACNR2 | |
| SCHEMBL3978572 | 0.80 | PCSK9 (0.40) | ALDH1A1POLBLMNAPSEN1PSEN2 | |
| SCHEMBL3972624 | 0.79 | POLB (0.55) | NR4A2ALDH1A1POLBLMNAMEN1 | |
| SCHEMBL4259652 | 0.78 | NR4A2 (0.34) | NR4A2ALDH1A1LMNAABCG2MEN1 | |
| SCHEMBL4257184 | 0.78 | PCSK9 (0.36) | NR4A2ALDH1A1POLBLMNACNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2065382-A1 | CGRP antagonists | Boehringer Ingelheim Pharma GmbH & Co. KG (DE) | 2009-06-03 | — | — | EP | disclosed |
| WO-2009050235-A1 | CGRP ANTAGONISTS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2009-04-23 | — | — | WO | disclosed |