SCHEMBL399324

SCHEMBL399324

C[C@H]1O[C@@H](n2ccc(N)nc2=O)C(O)C1O

nearest known ligand 0.67

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LMNA P02545 3/20 0.67
THRB P10828 1/20 0.67
MTOR P42345 1/20 0.67
MDM2 Q00987 1/20 0.67
NCOA1 Q15788 1/20 0.67
NCOA3 Q9Y6Q9 1/20 0.67
NT5E P21589 1/20 0.55
L3MBTL1 Q9Y468 1/20 0.53
TSHR P16473 1/20 0.49
GLA P06280 1/20 0.49
PDE3A Q14432 3/20 0.47
PDE4D Q08499 1/20 0.47
SLC29A1 Q99808 1/20 0.47
P2RY2 P41231 1/20 0.47
CACNA1F O60840 2/20 0.45
ALB P02768 2/20 0.45
MAPT P10636 2/20 0.45
CACNA1D Q01668 2/20 0.45
CACNA1S Q13698 2/20 0.45
CACNA1C Q13936 2/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10015791 1.00 LMNA (0.67) LMNATHRBMTORMDM2NCOA1
SCHEMBL399323 1.00 LMNA (0.67) LMNATHRBMTORMDM2NCOA1
SCHEMBL4879682 1.00 LMNA (0.67) LMNATHRBMTORMDM2NCOA1
Phosphoric Acid SCHEMBL3100818 0.95 LMNA (0.62) LMNATHRBMTORMDM2NCOA1
Phosphoric Acid SCHEMBL1299876 0.95 LMNA (0.62) LMNATHRBMTORMDM2NCOA1
Pyrophosphoric Acid SCHEMBL3100835 0.90 LMNA (0.57) LMNATHRBMTORMDM2NCOA1
SCHEMBL24337513 0.90 LMNA (0.62) LMNATHRBMTORMDM2NCOA1
SCHEMBL14929500 0.90 LMNA (0.59) LMNATHRBMTORMDM2NCOA1
SCHEMBL10015807 0.90 LMNA (0.59) LMNATHRBMTORMDM2NCOA1
Triphosphate SCHEMBL31006154 0.88 P2RY2 (0.55) LMNATHRBMTORMDM2NCOA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 92 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-115581703-A Compound gemcitabine composition and application thereof 江苏集萃分子工程研究院有限公司 2023-01-10 CN claimed
EP-0787138-B1 RADIOACTIVE PHOSPHOROUS LABELING OF PROTEINS FOR TARGETED RADIOTHERAPY IMMUNOMEDICS INC (US) 2006-06-28 EP claimed
EP-0787138-A4 RADIOACTIVE PHOSPHOROUS LABELING OF PROTEINS FOR TARGETED RADIOTHERAPY IMMUNOMEDICS INC (US) 2000-03-08 EP claimed
US-5976492-A Radioactive phosphorus labeled proteins for targeted radiotherapy IMMUNOMEDICS, INC. (US) 1999-11-02 US claimed
US-5728369-A Radioactive phosphorus labeling of proteins for targeted radiotherapy IMMUNOMEDICS, INC. (US) 1998-03-17 US claimed
EP-0787138-A1 RADIOACTIVE PHOSPHOROUS LABELING OF PROTEINS FOR TARGETED RADIOTHERAPY Immunomedics, Inc. (US) 1997-08-06 EP claimed
WO-1996011208-A1 RADIOACTIVE PHOSPHOROUS LABELING OF PROTEINS FOR TARGETED RADIOTHERAPY IMMUNOMEDICS, INC. (US) 1996-04-18 WO claimed
JP-10330395-A None JP disclosed
US-20240166675-A1 NOVEL PHOSPHOROUS (V)-BASED REAGENTS, PROCESSES FOR THE PREPARATION THEREOF, AND THEIR USE IN MAKING STEREO-DEFINED ORGANOPHOSHOROUS (V) COMPOUNDS BRISTOL-MYERS SQUIBB COMPANY 2024-05-23 US disclosed
EP-3851030-B1 MEDICAL DEVICE FOR ANALYTE MONITORING LABRADOR DIAGNOSTICS LLC (US) 2024-01-17 EP disclosed
US-20230034174-A1 IMMUNOMODULATING TUMOR NECROSIS FACTOR RECEPTOR 25 (TNFR25) AGONISTS, ANTAGONISTS, AND IMMUNOTOXINS UNIVERSITY OF MIAMI 2023-02-02 US disclosed
CN-115581703-A Compound gemcitabine composition and application thereof 江苏集萃分子工程研究院有限公司 2023-01-10 CN disclosed
US-11395846-B2 Immunomodulating tumor necrosis factor receptor 25 (TNFR25) agonists, antagonists, and immunotoxins UNIVERSITY OF MIAMI (US) 2022-07-26 US disclosed
EP-0882734-A2 5'-Deoxy-cytidine derivatives F. HOFFMANN-LA ROCHE AG (CH) 1998-12-09 EP disclosed
EP-0882734-A2 5'-Deoxy-cytidine derivatives F. HOFFMANN-LA ROCHE AG (CH) 1998-12-09 EP disclosed
EP-0882734-A2 5'-Deoxy-cytidine derivatives F. HOFFMANN-LA ROCHE AG (CH) 1998-12-09 EP disclosed
CN-1201037-A 5'-deoxy-cytidine derivatives HOFFMANN LA ROCHE (CH) 1998-12-09 CN disclosed
CN-1201037-A 5'-deoxy-cytidine derivatives HOFFMANN LA ROCHE (CH) 1998-12-09 CN disclosed
US-5728369-A Radioactive phosphorus labeling of proteins for targeted radiotherapy IMMUNOMEDICS, INC. (US) 1998-03-17 US disclosed
US-4071680-A ANTITUMOR AGENTS HOFFMANN-LA ROCHE INC. (US) 1978-01-31 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240166675-A1 NOVEL PHOSPHOROUS (V)-BASED REAGENTS, PROCESSES FOR THE PREPARATION THEREOF, AND THEIR USE IN MAKING STEREO-DEFINED ORGANOPHOSHOROUS (V) COMPOUNDS PPIP5K2, NUDT1, NT5C3B LMNA 3045/4885THRB 3628/4885MTOR 2024/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.