Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.46 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 3/20 | 0.40 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.40 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.40 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.40 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2819406 | 0.83 | L3MBTL1 (0.42) | ALDH1A1MAPTMAPK1PARP10MEN1 | |
| SCHEMBL2812294 | 0.81 | KDM4E (0.48) | MAPTLMNAMEN1KMT2ANPC1 | |
| SCHEMBL3989813 | 0.80 | POLB (0.45) | MAPTMEN1KMT2ANPC1RAB9A | |
| SCHEMBL2816636 | 0.79 | KDM4E (0.46) | LMNAMEN1KMT2AMAOBFFAR1 | |
| SCHEMBL2817001 | 0.79 | KDM4E (0.46) | MAPTNR1H4MEN1KMT2ANPC1 | |
| SCHEMBL2815448 | 0.79 | PPARD (0.46) | MAOBPTGDR2 | |
| SCHEMBL2816392 | 0.79 | KDM4E (0.51) | ALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL25718580 | 0.78 | RAB9A (0.49) | ALDH1A1MAPTPARP10NR1H4LMNA | |
| SCHEMBL3998867 | 0.78 | PLA2G4B (0.42) | ALDH1A1MAPTCYP3A4LMNAMEN1 | |
| SCHEMBL2816973 | 0.78 | ALOX5 (0.41) | ALDH1A1MAPTMAOBPTGDR2FFAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8362057-B2 | Insulin resistance; atherosclerosis; cardiovascular disorders; metabolism disorders | MERCK Patent Gesellschaft mit beschränkter Haftung (DE) | 2013-01-29 | — | — | US | disclosed |
| EP-1910310-B1 | NOVELIMIDAZOLECARBOXAMIDE DERIVATIVES AS FRUCTOSE-1,6-BISPHOSPHATASE INHIBITORS, AND PHARMACEUTICAL COMPOSITIONS COMPRISING SAME | MERCK PATENT GMBH (DE) | 2009-06-03 | — | — | EP | disclosed |
| US-20080207720-A1 | Novel Imidazolecarboxamide Derivatives as Fructose-1,6-Bisphosphatase Inhibitors, and Pharmaceutical Compositions Comprising Same | MERCK PATENT GESELLSCHAFT (DE) | 2008-08-28 | — | — | US | disclosed |
| EP-1910310-A1 | NOVELIMIDAZOLECARBOXAMIDE DERIVATIVES AS FRUCTOSE-1,6-BISPHOSPHATASE INHIBITORS, AND PHARMACEUTICAL COMPOSITIONS COMPRISING SAME | Merck Patent GmbH (DE) | 2008-04-16 | — | — | EP | disclosed |
| WO-2007014619-A1 | NOVELIMIDAZOLECARBOXAMIDE DERIVATIVES AS FRUCTOSE-1,6-BISPHOSPHATASE INHIBITORS, AND PHARMACEUTICAL COMPOSITIONS COMPRISING SAME | MERCK PATENT GMBH (DE) | 2007-02-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080207720-A1 | Novel Imidazolecarboxamide Derivatives as Fructose-1,6-Bisphosphatase Inhibitors, and Pharmaceutical Compositions Comprising Same | FBP1, INSR, GPR119 | ALDH1A1 478/4885MAPT 3535/4885MAPK1 674/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.