Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.47 |
| ▸ | MMP13 | P45452 | 3/20 | 0.47 |
| ▸ | MMP1 | P03956 | 2/20 | 0.47 |
| ▸ | CA1 | P00915 | 1/20 | 0.46 |
| ▸ | CA2 | P00918 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6825821 | 0.82 | ALDH1A1 (0.64) | KMT2APAX8MMP13MMP1CA1 | |
| SCHEMBL10258225 | 0.81 | PLCG1 (0.55) | KMT2AMMP13MMP1CA2ALDH1A1 | |
| SCHEMBL4010614 | 0.80 | CA1 (0.49) | KMT2APAX8MMP13MMP1CA1 | |
| SCHEMBL2448610 | 0.80 | PSIP1 (0.56) | KMT2AMMP13MMP1ALDH1A1HSD11B1 | |
| SCHEMBL29296587 | 0.79 | CA2 (0.50) | KMT2AMMP13MMP1CA2ALDH1A1 | |
| SCHEMBL16473940 | 0.79 | KMT2A (0.46) | KMT2APAX8MMP13MMP1CA1 | |
| SCHEMBL1272371 | 0.79 | GBA1 (0.40) | KMT2AMMP13MMP1CA1CA2 | |
| SCHEMBL29296550 | 0.78 | MMP13 (0.76) | KMT2AMMP13MMP1ALDH1A1 | |
| SCHEMBL1368369 | 0.78 | L3MBTL1 (0.53) | KMT2APAX8CA1CA2ALDH1A1 | |
| SCHEMBL9439294 | 0.78 | GAA (0.43) | KMT2AMMP13MMP1CA2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2074098-A2 | QUINOLINE COMPOUNDS | Wyeth (US) | 2009-07-01 | — | — | EP | disclosed |
| WO-2008049047-A2 | QUINOLINE COMPOUNDS | WYETH (US) | 2008-04-24 | — | — | WO | disclosed |