SCHEMBL4016263

SCHEMBL4016263

COC(=O)c1ccc(C(F)(F)F)nc1S(=O)(=O)N(C(N)=O)c1nc(OC)cc(OC)n1

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TUBB4A P04350 1/20 0.43
TUBB P07437 1/20 0.43
TUBA3C P0DPH7 1/20 0.43
TUBA1B P68363 1/20 0.43
TUBA4A P68366 1/20 0.43
TUBB4B P68371 1/20 0.43
TUBB3 Q13509 1/20 0.43
TUBB2A Q13885 1/20 0.43
TUBB8 Q3ZCM7 1/20 0.43
TUBA3E Q6PEY2 1/20 0.43
TUBA1A Q71U36 1/20 0.43
TUBA1C Q9BQE3 1/20 0.43
TUBB6 Q9BUF5 1/20 0.43
TUBB2B Q9BVA1 1/20 0.43
TUBB1 Q9H4B7 1/20 0.43
SDHB P21912 2/20 0.37
TSHR P16473 2/20 0.37
CFTR P13569 1/20 0.36
GAA P10253 4/20 0.36
L3MBTL1 Q9Y468 3/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1535820 0.99 TUBB4A (0.42) TUBB4ATUBBTUBA3CTUBA1BTUBA4A
SCHEMBL27546428 0.90 TSHR (0.35) TUBB4ATUBBTUBA3CTUBA1BTUBA4A
SCHEMBL733528 0.76 GAA (0.61) TUBB4ATUBBTUBA3CTUBA1BTUBA4A
SCHEMBL30116876 0.76 GAA (0.61) TUBB4ATUBBTUBA3CTUBA1BTUBA4A
SCHEMBL1535823 0.76 GAA (0.61) TUBB4ATUBBTUBA3CTUBA1BTUBA4A
SCHEMBL1535822 0.76 GAA (0.60) TUBB4ATUBBTUBA3CTUBA1BTUBA4A
SCHEMBL8446293 0.75 TUBB4A (0.49) TUBB4ATUBBTUBA3CTUBA1BTUBA4A
SCHEMBL29455295 0.75 TUBB4A (0.42) TUBB4ATUBBTUBA3CTUBA1BTUBA4A
SCHEMBL9452140 0.74 CA1 (0.40) TSHRL3MBTL1SMN1; SMN2ALDH1A1KMT2A
SCHEMBL8540548 0.73 TUBB4A (0.50) TUBB4ATUBBTUBA3CTUBA1BTUBA4A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 44 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20170042157-A1 HERBICIDE COMBINATIONS COMPRISING SPECIFIC SULFONYLUREAS BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) 2017-02-16 US disclosed
US-20140243199-A1 HERBICIDE COMBINATIONS COMPRISING SPECIFIC SULFONYLUREAS BAYER CROPSCIENCE AG (DE) 2014-08-28 US disclosed
EP-1898705-B1 OIL SUSPENSION CONCENTRATE BAYER CROPSCIENCE AG (DE) 2009-10-14 EP disclosed
EP-1482801-B1 HERBICIDE COMBINATIONS WITH SPECIAL SULFONYLUREAS BAYER CROPSCIENCE AG (DE) 2009-06-24 EP disclosed
EP-1651045-B1 TERNARY HERBICIDAL COMBINATIONS COMPRISING SPECIAL SULPHONAMIDES BAYER CROPSCIENCE AG (DE) 2009-03-11 EP disclosed
US-20080287296-A1 Herbicide Combinations Comprising Specific Sulfonylureas BAYER CROPSCIENCE AG (DE) 2008-11-20 US disclosed
EP-1482799-B1 HERBICIDE COMBINATIONS WITH SPECIAL SULFONYLUREAS BAYER CROPSCIENCE AG (DE) 2008-05-21 EP disclosed
EP-1898705-A1 OIL SUSPENSION CONCENTRATE Bayer CropScience AG (DE) 2008-03-19 EP disclosed
EP-1890542-A1 HERBICIDES BAYER CROPSCIENCE AG (DE) 2008-02-27 EP disclosed
EP-1651047-B1 HERBICIDE COMBINATIONS WITH SPECIFIC SULFONAMIDES BAYER CROPSCIENCE AG (DE) 2007-12-19 EP disclosed
EP-1104239-B1 HERBICIDES WITH ACYLATED AMINOPHENYLSULFONYL UREA BAYER CROPSCIENCE GMBH (DE) 2004-02-18 EP disclosed
US-20030186816-A1 For controlling undesired plant growth BAYER CROPSCIENCE GMBH (DE) 2003-10-02 US disclosed
WO-2003073854-A1 HERBICIDE COMBINATIONS WITH SPECIAL SULFONYLUREAS BAYER CROPSCIENCE GMBH (DE) 2003-09-12 WO disclosed
WO-2003073855-A1 HERBICIDE COMBINATIONS WITH SPECIAL SULFONYLUREAS BAYER CROPSCIENCE GMBH (DE) 2003-09-12 WO disclosed
WO-2003009684-A2 HERBICIDAL COMBINATIONS WITH PARTICULAR SULPHONYL UREAS BAYER CROP-SCIENCE GMBH (DE) 2003-02-06 WO disclosed
US-6486096-B1 Herbicidal compositions with acylated aminophenylsulfonylureas HOECHST SCHERING AGREVO GMBH (DE) 2002-11-26 US disclosed
US-6365753-B1 EXCELLENT PREFERENTIAL EFFECTS ON WEEDS; GRASSES; NONPHYTOTOXIC TO CROPS E.G. WHEAT; BARLEY; CORN MITSUBISHI CHEMICAL CORPORATION (JP) 2002-04-02 US disclosed
EP-1104239-A1 HERBICIDES WITH ACYLATED AMINOPHENYLSULFONYL UREA Aventis CropScience GmbH (DE) 2001-06-06 EP disclosed
EP-1097923-A1 PHTHALIMIDES AND HERBICIDE CONTAINING THE SAME AS ACTIVE COMPONENT MITSUBISHI CHEMICAL CORPORATION (JP) 2001-05-09 EP disclosed
WO-2000008932-A1 HERBICIDES WITH ACYLATED AMINOPHENYLSULFONYL UREA AVENTIS CROPSCIENCE GMBH (DE) 2000-02-24 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20170042157-A1 HERBICIDE COMBINATIONS COMPRISING SPECIFIC SULFONYLUREAS GSTM2, GSTM1, CHRM2 TUBB4A 1224/4885TUBB 786/4885TUBA3C 502/4885
US-20080287296-A1 Herbicide Combinations Comprising Specific Sulfonylureas SLC16A3, SLC16A7, SLC16A1 TUBB4A 688/4885TUBB 534/4885TUBA3C 269/4885
US-20140243199-A1 HERBICIDE COMBINATIONS COMPRISING SPECIFIC SULFONYLUREAS SLC16A3, SLC16A7, MTX2 TUBB4A 721/4885TUBB 563/4885TUBA3C 281/4885
US-20030186816-A1 For controlling undesired plant growth MTX2, DDT, METAP2 TUBB4A 279/4885TUBB 175/4885TUBA3C 118/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.