SCHEMBL4018942

SCHEMBL4018942

C=Cc1c(CC)cncc1CC

nearest known ligand 0.37

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
PDXK O00764 1/20 0.37
HDAC8 Q9BY41 1/20 0.35
LMNA P02545 1/20 0.34
SMN1; SMN2 Q16637 1/20 0.34
L3MBTL1 Q9Y468 1/20 0.34
NOS3 P29474 1/20 0.30
NOS1 P29475 1/20 0.30
NOS2 P35228 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11549010 0.82 GRM5 (0.38) PDXKHDAC8
SCHEMBL9070349 0.74 THRA (0.39) L3MBTL1
SCHEMBL1363486 0.72 GABRA1 (0.50) LMNASMN1; SMN2L3MBTL1
SCHEMBL36439 0.72 CCNC (0.39) LMNASMN1; SMN2L3MBTL1
SCHEMBL7129083 0.70 DHFR (0.36) NOS3NOS1NOS2
SCHEMBL20326527 0.70 NOS3 (0.38) NOS3NOS1NOS2
SCHEMBL20621289 0.70 GRK2 (0.37)
SCHEMBL20621224 0.70
SCHEMBL1264399 0.70 MEN1 (0.46) SMN1; SMN2
SCHEMBL24982066 0.69 NOS3 (0.32) NOS3NOS1NOS2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 46 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4157430-A Amine terminated polymers and the formation of block copolymers THE FIRESTONE TIRE & RUBBER COMPANY (US) 1979-06-05 US claimed
US-4157429-A Amine terminated polymers and the formation of block copolymers THE FIRESTONE TIRE & RUBBER COMPANY (US) 1979-06-05 US claimed
US-4155947-A Amine terminated polymers and the formation of blocked copolymers THE FIRESTONE TIRE & RUBBER COMPANY (US) 1979-05-22 US claimed
US-4155948-A Amine terminated polymers and the formation of blocked copolymers THE FIRESTONE TIRE & RUBBER COMPANY (US) 1979-05-22 US claimed
US-4154773-A UREA-ALDEHYDE POLYMER COUPLED TO ADDITION POLYMER THE FIRESTONE TIRE & RUBBER COMPANY (US) 1979-05-15 US claimed
US-4154772-A PHENOLIC RESIN CONNECTED TO ADDITION POLYMER THE FIRESTONE TIRE & RUBBER COMPANY (US) 1979-05-15 US claimed
US-4154913-A ADDITION POLYMER ENDCAPPED WITH POLYISOCYANATE THE FIRESTONE TIRE & RUBBER COMPANY (US) 1979-05-15 US claimed
US-4070344-A WITH POLYISOCYANATE, AMIDE, HYDROLYSIS THE FIRESTONE TIRE AND RUBBER COMPANY (US) 1978-01-24 US claimed
CN-100562529-C Curable sealant composition BRIDGESTONE CORP (JP) 2009-11-25 CN disclosed
US-7608664-B2 Curable sealant composition and method for manufacturing same BRIDGESTONE CORPORATION (JP) 2009-10-27 US disclosed
US-7517936-B2 Curable sealant composition BRIDGESTONE CORPORATION (JP) 2009-04-14 US disclosed
US-20080161491-A1 Curable Sealant Composition and Method for Manufacturing Same BRIDGESTONE CORPORATION (JP) 2008-07-03 US disclosed
EP-1611166-B1 BUILDING SEALANT COMPOSITION BRIDGESTONE CORP (JP) 2007-08-29 EP disclosed
US-20060217489-A1 Building sealant composition BRIDGESTONE CORPORATION (JP) 2006-09-28 US disclosed
US-4154913-A ADDITION POLYMER ENDCAPPED WITH POLYISOCYANATE THE FIRESTONE TIRE & RUBBER COMPANY (US) 1979-05-15 US disclosed
US-4151222-A Amine terminated polymers and the formation of block copolymers THE FIRESTONE TIRE & RUBBER COMPANY (US) 1979-04-24 US disclosed
US-4072807-A OLEFIN DISPROPORTIONATION CATALYST PHILLIPS PETROLEUM COMPANY (US) 1978-02-07 US disclosed
US-4070344-A WITH POLYISOCYANATE, AMIDE, HYDROLYSIS THE FIRESTONE TIRE AND RUBBER COMPANY (US) 1978-01-24 US disclosed
US-3995095-A Modification of polymers by treatment with olefins PHILLIPS PETROLEUM COMPANY (US) 1976-11-30 US disclosed
US-3977923-A Method and solid propellant with unsaturated aziridine cured binder THE GENERAL TIRE & RUBBER COMPANY (US) 1976-08-31 US disclosed