Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.56 |
| ▸ | SRC | P12931 | 1/20 | 0.45 |
| ▸ | CES1 | P23141 | 4/20 | 0.43 |
| ▸ | CES2 | O00748 | 3/20 | 0.43 |
| ▸ | HPGD | P15428 | 3/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | F2 | P00734 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | DAO | P14920 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1603720 | 1.00 | TSHR (0.56) | TSHRSRCCES1CES2HPGD | |
| SCHEMBL10873087 | 1.00 | TSHR (0.56) | TSHRSRCCES1CES2HPGD | |
| SCHEMBL9311224 | 0.89 | TSHR (0.52) | TSHRSRCCES1CES2HPGD | |
| SCHEMBL7039288 | 0.88 | TSHR (0.46) | TSHRSRCCES1CES2HPGD | |
| SCHEMBL16213551 | 0.88 | CES2 (0.52) | TSHRCES2KMT2ATDP1MEN1 | |
| SCHEMBL4797237 | 0.87 | TSHR (0.50) | TSHRSRCCES1CES2HPGD | |
| SCHEMBL7763555 | 0.86 | TSHR (0.45) | TSHRCES1CES2HPGDKMT2A | |
| SCHEMBL4629606 | 0.85 | TSHR (0.48) | TSHRSRCCES1CES2HPGD | |
| SCHEMBL1055303 | 0.83 | TSHR (0.46) | TSHRSRCCES1CES2HPGD | |
| SCHEMBL3309374 | 0.83 | TSHR (0.46) | TSHRSRCCES1CES2HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7507851-B2 | Halocombstatins and methods of synthesis thereof | ARIZONA BOARD OF REGENTS, A STATE CORPORATE OF THE STATE OF ARIZONA, ACTING FOR AND ON BEHALF OF ARIZONA STATE UNIVERSITY (US) | 2009-03-24 | — | — | US | disclosed |
| US-20080119649-A1 | HALOCOMBSTATINS AND METHODS OF SYNTHESIS THEREOF | ARIZONA BOARD OF REGENTS, A BODY CORPORATE OF THE STATE OF ARIZONA, ACTING FOR AND ON BEHALF OF ARIZONA STATE UNIVERSITY | 2008-05-22 | — | — | US | disclosed |
| EP-1802560-A2 | HALOCOMBSTATINS AND METHODS OF SYNTHESIS THEREOF | Arizona Board Regents, a body corporate of the State of Arizona, acting for and on behalf of Arizona State University (US) | 2007-07-04 | — | — | EP | disclosed |
| WO-2006036743-A2 | HALOCOMBSTATINS AND METHODS OF SYNTHESIS THEREOF | ARIZONA BOARD OF REGENTS, A BODY CORPORATE OF THE STATE OF ARIZONA ACTING FOR AND ON BEHALF OF ARIZONA STATE UNIVERSITY (US) | 2006-04-06 | — | — | WO | disclosed |
| EP-0141271-A3 | TALL OIL FATTY ACIDS - QUALITY IMPROVEMENT | ARIZONA CHEMICAL COMPANY (US) | 1986-02-05 | — | — | EP | disclosed |
| US-4536332-A | ISOMERIZING TRANS-DIMETHOXYSTILBENE TO CIS CONFIGURATION, DISTILLING OUT | ARIZONA CHEMICAL COMPANY (US) | 1985-08-20 | — | — | US | disclosed |
| EP-0141271-A2 | Tall oil fatty acids - quality improvement | ARIZONA CHEMICAL COMPANY (US) | 1985-05-15 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080119649-A1 | HALOCOMBSTATINS AND METHODS OF SYNTHESIS THEREOF | TUBB3, TUBB8B, TUBB8 | TSHR 3150/4885SRC 2392/4885CES1 2509/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.