SCHEMBL4019593

SCHEMBL4019593

NOCc1cc(Cl)ccc1Cl

nearest known ligand 0.70

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
IDO1 P14902 18/20 0.70
AGXT P21549 5/20 0.50
CYP3A4 P08684 2/20 0.48
TP53 P04637 2/20 0.43
TSHR P16473 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL2514135 0.98 IDO1 (0.71) IDO1AGXTCYP3A4TP53TSHR
SCHEMBL9767549 0.83 IDO1 (1.00) IDO1AGXTCYP3A4
Hydrochloric Acid SCHEMBL1715908 0.81 IDO1 (1.00) IDO1AGXTCYP3A4
Hydrochloric Acid SCHEMBL1715890 0.81 IDO1 (1.00) IDO1AGXTCYP3A4
SCHEMBL12873450 0.80 IDO1 (0.45) IDO1CYP3A4TP53TSHR
SCHEMBL1520857 0.79 IDO1 (0.54) IDO1AGXTCYP3A4TP53
SCHEMBL1145754 0.78 IDO1 (0.44) IDO1CYP3A4TP53TSHR
SCHEMBL1145751 0.78 IDO1 (0.44) IDO1CYP3A4TP53TSHR
SCHEMBL1520724 0.76 IDO1 (0.56) IDO1AGXTCYP3A4
SCHEMBL11007814 0.76 IDO1 (0.66) IDO1AGXTCYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-115362161-B Process for preparing 3' -O-amino-2 ' -deoxyribonucleoside-5 ' -triphosphate DNA斯克瑞普特公司 2025-03-07 CN claimed
US-11661436-B2 Method for preparing 3′-o-amino-2′-deoxyribonucleoside-5′-triphosphates DNA SCRIPT SAS (FR) 2023-05-30 US claimed
EP-4126895-A1 METHOD FOR PREPARING 3'-O-AMINO-2'-DEOXYRIBONUCLEOSIDE-5'-TRIPHOSPHATES DNA Script (FR) 2023-02-08 EP claimed
CN-115362161-A Process for preparing 3' -O-amino-2 ' -deoxyribonucleoside-5 ' -triphosphates DNA斯克瑞普特公司 2022-11-18 CN claimed
US-20210300961-A1 METHOD FOR PREPARING 3'-O-AMINO-2'-DEOXYRIBONUCLEOSIDE-5'-TRIPHOSPHATES DNA SCRIPT SAS (FR) 2021-09-30 US claimed
CN-115362161-B Process for preparing 3' -O-amino-2 ' -deoxyribonucleoside-5 ' -triphosphate DNA斯克瑞普特公司 2025-03-07 CN disclosed
US-11661436-B2 Method for preparing 3′-o-amino-2′-deoxyribonucleoside-5′-triphosphates DNA SCRIPT SAS (FR) 2023-05-30 US disclosed
EP-4126895-A1 METHOD FOR PREPARING 3'-O-AMINO-2'-DEOXYRIBONUCLEOSIDE-5'-TRIPHOSPHATES DNA Script (FR) 2023-02-08 EP disclosed
CN-115362161-A Process for preparing 3' -O-amino-2 ' -deoxyribonucleoside-5 ' -triphosphates DNA斯克瑞普特公司 2022-11-18 CN disclosed
WO-2021198040-A1 METHOD FOR PREPARING 3'-O-AMINO-2'-DEOXYRIBONUCLEOSIDE-5'-TRIPHOSPHATES. DNA SCRIPT (FR) 2021-10-07 WO disclosed
US-20210300961-A1 METHOD FOR PREPARING 3'-O-AMINO-2'-DEOXYRIBONUCLEOSIDE-5'-TRIPHOSPHATES DNA SCRIPT SAS (FR) 2021-09-30 US disclosed
US-8247413-B2 e.g. N-[2-(3-fluorophenyl)ethyl]-N'-isoquinolin-5-ylurea; opioid receptor inhibitor; analgesic, antiinflammatory agent; inflammatory thermal hyperalgesia, urinary incontinence and bladder overactivity ABBOTT LABORATORIES (US) 2012-08-21 US disclosed
US-20080214524-A1 FUSED AZABICYCLIC COMPOUNDS THAT INHIBIT VANILLOID RECEPTOR SUBTYPE 1 (VR1) RECEPTOR ABBOTT LABORATORIES (US) 2008-09-04 US disclosed
US-7335678-B2 Fused azabicyclic compounds that inhibit vanilloid receptor subtype 1(VR1) receptor ABBOTT LABORATORIES (US) 2008-02-26 US disclosed
US-6933311-B2 Fused azabicyclic compounds that inhibit vanilloid receptor subtype 1 (VR1) receptor ABBOTT LABORATORIES (US) 2005-08-23 US disclosed
US-20050113576-A1 Fused azabicyclic compounds that inhibit vanilloid receptor subtype 1 (VR1) receptor ABBOTT LABORATORIES 2005-05-26 US disclosed
US-20040209884-A1 Fused azabicycic compounds that inhibit vanilloid receptor subtype 1(VR1) receptor ABBVIE INC. 2004-10-21 US disclosed
US-20040157849-A1 Fused azabicyclic compounds that inhibit vanilloid receptor subtype 1 (VR1) receptor ABBVIE INC. 2004-08-12 US disclosed
US-20030158198-A1 Fused azabicyclic compounds that inhibit vanilloid receptor subtype 1 (VR1) receptor ABBVIE INC. 2003-08-21 US disclosed
US-4293715-A FUNGICIDES, BACTERICIDES BAYER AKTIENGESELLSCHAFT (DE) 1981-10-06 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080214524-A1 FUSED AZABICYCLIC COMPOUNDS THAT INHIBIT VANILLOID RECEPTOR SUBTYPE 1 (VR1) RECEPTOR TRPV1, TMEM109, VIPR1 IDO1 1470/4885AGXT 4213/4885CYP3A4 1234/4885
US-20210300961-A1 METHOD FOR PREPARING 3'-O-AMINO-2'-DEOXYRIBONUCLEOSIDE-5'-TRIPHOSPHATES DUT, RNMT, NUDT1 IDO1 997/4885AGXT 971/4885CYP3A4 825/4885
US-20030158198-A1 Fused azabicyclic compounds that inhibit vanilloid receptor subtype 1 (VR1) receptor TRPV1, VIPR1, TMEM109 IDO1 1232/4885AGXT 4158/4885CYP3A4 1208/4885
US-20040157849-A1 Fused azabicyclic compounds that inhibit vanilloid receptor subtype 1 (VR1) receptor TRPV1, VIPR1, TMEM109 IDO1 1192/4885AGXT 4234/4885CYP3A4 1191/4885
US-11661436-B2 Method for preparing 3′-o-amino-2′-deoxyribonucleoside-5′-triphosphates DUT, RNMT, NUDT1 IDO1 984/4885AGXT 924/4885CYP3A4 879/4885
US-20040209884-A1 Fused azabicycic compounds that inhibit vanilloid receptor subtype 1(VR1) receptor TRPV1, TMEM109, GPR55 IDO1 859/4885AGXT 4192/4885CYP3A4 1162/4885
US-20050113576-A1 Fused azabicyclic compounds that inhibit vanilloid receptor subtype 1 (VR1) receptor TRPV1, TMEM109, VIPR1 IDO1 1470/4885AGXT 4213/4885CYP3A4 1234/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.