SCHEMBL4021295

SCHEMBL4021295

C=C(c1ccccc1)C(C)Cl

nearest known ligand 0.61

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LMNA P02545 3/20 0.47
SMN1; SMN2 Q16637 3/20 0.47
ATM Q13315 3/20 0.47
MAPT P10636 2/20 0.47
NPSR1 Q6W5P4 2/20 0.47
XBP1 P17861 1/20 0.47
ALDH1A1 P00352 4/20 0.43
HPGD P15428 1/20 0.39
L3MBTL1 Q9Y468 1/20 0.39
MEN1 O00255 1/20 0.38
KMT2A Q03164 1/20 0.38
HSP90AA1 P07900 2/20 0.37
NPC1 O15118 1/20 0.37
GAA P10253 1/20 0.37
RAB9A P51151 1/20 0.37
TSHR P16473 3/20 0.35
CES2 O00748 2/20 0.35
CES1 P23141 2/20 0.35
DAO P14920 1/20 0.35
NAPRT Q6XQN6 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL693987 0.80 SMN1; SMN2 (0.50) LMNASMN1; SMN2ATMMAPTNPSR1
SCHEMBL9524578 0.79 CES2 (0.41) LMNASMN1; SMN2ATMMAPTNPSR1
SCHEMBL9522141 0.79 CES2 (0.41) LMNASMN1; SMN2ATMMAPTNPSR1
Hydrogen Sulfide SCHEMBL29028321 0.78 SMN1; SMN2 (0.48) LMNASMN1; SMN2ATMMAPTNPSR1
SCHEMBL3731992 0.78 LMNA (0.48) LMNASMN1; SMN2ATMMAPTNPSR1
SCHEMBL9051012 0.78 ALDH1A1 (0.35) LMNASMN1; SMN2ATMMAPTNPSR1
SCHEMBL4662816 0.76 LMNA (0.47) LMNASMN1; SMN2ATMMAPTNPSR1
SCHEMBL830415 0.76 SMN1; SMN2 (0.47) LMNASMN1; SMN2ATMMAPTNPSR1
SCHEMBL7854232 0.76 SMN1; SMN2 (0.52) LMNASMN1; SMN2ATMMAPTNPSR1
SCHEMBL28985808 0.76 LMNA (0.39) LMNASMN1; SMN2ATMMAPTNPSR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1555273-B2 IMPROVED PROCESSES BASED ON ATOM (OR GROUP) TRANSFER RADICAL POLYMERIZATION AND NOVEL (CO) POLYMERS HAVING USEFUL STRUCTURES AND PROPERTIES UNIV CARNEGIE MELLON (US) 2014-09-17 EP disclosed
US-7572874-B2 Processes based on atom (or group) transfer radical polymerization and novel (co)polymers having useful structures and properties CARNEGIE MELLON UNIVERSITY (US) 2009-08-11 US disclosed
EP-1555273-B1 IMPROVED PROCESSES BASED ON ATOM (OR GROUP) TRANSFER RADICAL POLYMERIZATION AND NOVEL (CO) POLYMERS HAVING USEFUL STRUCTURES AND PROPERTIES UNIV CARNEGIE MELLON (US) 2009-02-25 EP disclosed
EP-0861272-B1 IMPROVED PROCESSES BASED ON ATOM (OR GROUP) TRANSFER RADICAL POLYMERIZATION AND NOVEL (CO)POLYMERS HAVING USEFUL STRUCTURES AND PROPERTIES UNIV CARNEGIE MELLON (US) 2006-07-05 EP disclosed
WO-2005073284-A2 HYPERBRANCHED POLYMERS THE UNIVERSITY OF SHEFFIELD (GB) 2005-08-11 WO disclosed
EP-1555273-A1 IMPROVED PROCESSES BASED ON ATOM (OR GROUP) TRANSFER RADICAL POLYMERIZATION AND NOVEL (CO) POLYMERS HAVING USEFUL STRUCTURES AND PROPERTIES CARNEGIE MELLON UNIVERSITY (US) 2005-07-20 EP disclosed
US-20050143546-A1 Processes based on atom (or group) transfer radical polymerization and novel (co)polymers having useful structures and properties CARNEGIE MELLON UNIVERSITY 2005-06-30 US disclosed
US-6887962-B2 Processes based on atom (or group) transfer radical polymerization and novel (co)polymers having useful structures and properties CARNEGIE MELLON UNIVERSITY (US) 2005-05-03 US disclosed
US-20030181619-A1 Processes based on atom (or group) transfer radical polymerization and novel (co) polymers having useful structures and properties CARNEGIE MELLON UNIVERSITY 2003-09-25 US disclosed
US-6538091-B1 Narrow molecular weight distribution; telechelic polymers; initiator residue CARNEGIE MELLON UNIVERSITY 2003-03-25 US disclosed
WO-2002024773-A2 BRANCHED POLYMERS, METHOD FOR THE PRODUCTION THEREOF, AND THEIR USE BASF AKTIENGESELLSCHAFT (DE) 2002-03-28 WO disclosed
US-5807937-A Processes based on atom (or group) transfer radical polymerization and novel (co) polymers having useful structures and properties CARNEGIE MELLON UNIVERSITY (US) 1998-09-15 US disclosed
EP-0861272-A1 IMPROVED PROCESSES BASED ON ATOM (OR GROUP) TRANSFER RADICAL POLYMERIZATION AND NOVEL (CO)POLYMERS HAVING USEFUL STRUCTURES AND PROPERTIES CARNEGIE MELLON UNIVERSITY (US) 1998-09-02 EP disclosed
WO-1997018247-A1 IMPROVED PROCESSES BASED ON ATOM (OR GROUP) TRANSFER RADICAL POLYMERIZATION AND NOVEL (CO)POLYMERS HAVING USEFUL STRUCTURES AND PROPERTIES CARNEGIE MELLON UNIVERSITY (US) 1997-05-22 WO disclosed
US-5491189-A BINDER DISPERSION CONSISTS OF A HALOGENATED COPOLYMER OF 2,3-DIHALO-1,3-BUTADIENE, AROMATIC MONOALKYENE ALKYL HALIDE, UNSATURATED OLEFIN, AND CONTAINS ADDITIVE, PARTLY SAPONIFIED VINYL ACETATE COPOLYMER, AROMATIC POLYNITROSO COMPOUNDS HENKEL KOMMANDITGESELLSCHAFT AUF AKTIEN (DE) 1996-02-13 US disclosed
EP-0470105-B1 AQUEOUS VULCANIZING ADHESIVE HENKEL KGAA (DE) 1994-07-27 EP disclosed
EP-0345455-B1 Composition for the surface treatment of polymer fibres HENKEL KGAA (DE) 1993-11-03 EP disclosed
EP-0470105-A1 AQUEOUS VULCANIZING ADHESIVE. HENKEL KGAA (DE) 1992-02-12 EP disclosed
WO-1990012847-A1 AQUEOUS VULCANIZING ADHESIVE HENKEL KOMMANDITGESELLSCHAFT AUF AKTIEN (DE) 1990-11-01 WO disclosed
EP-0345455-A2 Composition for the surface treatment of polymer fibres Henkel Kommanditgesellschaft auf Aktien (DE) 1989-12-13 EP disclosed