Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.36 |
| ▸ | GRM5 | P41594 | 1/20 | 0.36 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.35 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.32 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7110731 | 0.81 | TDP1 (0.40) | HDAC8PTGS2GRM5CHRNB2CHRNA4 | |
| SCHEMBL27849413 | 0.79 | ROCK2 (0.40) | PTGS2CHRNB2 | |
| SCHEMBL4906652 | 0.79 | ALDH1A1 (0.37) | SMYD3CHRNB2CHRNA4MAPTHTT | |
| SCHEMBL29955560 | 0.79 | ALDH1A1 (0.37) | SMYD3CHRNB2CHRNA4MAPTHTT | |
| SCHEMBL240843 | 0.77 | SMYD3 (0.39) | SMYD3CHRNB2CHRNA4MAPTHTT | |
| SCHEMBL6551393 | 0.77 | HDAC8 (0.46) | HDAC8PTGS2GRM5ALDH1A1 | |
| SCHEMBL420700 | 0.75 | ALDH1A1 (0.36) | HDAC8PTGS2ALDH1A1 | |
| SCHEMBL9000622 | 0.75 | ROCK2 (0.34) | PTGS2SMYD3CHRNB2CHRNA4 | |
| SCHEMBL6774970 | 0.73 | NAPRT (0.44) | PTGS2MAPTHTTALDH1A1 | |
| SCHEMBL20314431 | 0.73 | CYP11B1 (0.48) | GRM5CHRNB2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 64 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4211824-A | CONJUGATED DIENE-VINYL NITROGEN HETEROCYCLE INTERPOLYMER ADHESIVE | HONNY CHEMICALS COMPANY, LTD. (JP) | 1980-07-08 | — | — | US | claimed |
| US-4157429-A | Amine terminated polymers and the formation of block copolymers | THE FIRESTONE TIRE & RUBBER COMPANY (US) | 1979-06-05 | — | — | US | claimed |
| US-4157430-A | Amine terminated polymers and the formation of block copolymers | THE FIRESTONE TIRE & RUBBER COMPANY (US) | 1979-06-05 | — | — | US | claimed |
| US-4155947-A | Amine terminated polymers and the formation of blocked copolymers | THE FIRESTONE TIRE & RUBBER COMPANY (US) | 1979-05-22 | — | — | US | claimed |
| US-4155948-A | Amine terminated polymers and the formation of blocked copolymers | THE FIRESTONE TIRE & RUBBER COMPANY (US) | 1979-05-22 | — | — | US | claimed |
| US-4154772-A | PHENOLIC RESIN CONNECTED TO ADDITION POLYMER | THE FIRESTONE TIRE & RUBBER COMPANY (US) | 1979-05-15 | — | — | US | claimed |
| US-4154773-A | UREA-ALDEHYDE POLYMER COUPLED TO ADDITION POLYMER | THE FIRESTONE TIRE & RUBBER COMPANY (US) | 1979-05-15 | — | — | US | claimed |
| US-4154913-A | ADDITION POLYMER ENDCAPPED WITH POLYISOCYANATE | THE FIRESTONE TIRE & RUBBER COMPANY (US) | 1979-05-15 | — | — | US | claimed |
| US-4096009-A | METAL DEPOSITION, VINYL PYRIDINE COPOLYMERS | HONNY CHEMICALS COMPANY, LTD. (JA) | 1978-06-20 | — | — | US | claimed |
| US-4070344-A | WITH POLYISOCYANATE, AMIDE, HYDROLYSIS | THE FIRESTONE TIRE AND RUBBER COMPANY (US) | 1978-01-24 | — | — | US | claimed |
| US-4049875-A | Bonding rubber to ferrous metal through a deposit of copper and adhesive and laminate therefrom | HONNY CHEMICALS COMPANY, LTD. (JA) | 1977-09-20 | — | — | US | claimed |
| US-3998992-A | DIENE INTERPOLYMER ADHESIVE | HONNY CHEMICALS CO., LTD. (JA) | 1976-12-21 | — | — | US | claimed |
| US-3993847-A | RUBBER BONDED TO FERROUS METAL, INTERPOLYMER OF CONJUGATED DIENE AND HETEROCYCLIC NITROGEN BASE | HONNY CHEMICALS COMPANY, LTD. (JA) | 1976-11-23 | — | — | US | claimed |
| US-11807624-B2 | Substituted pyrimidinones as agonists of the APJ receptor | AMGEN INC. (US) | 2023-11-07 | — | — | US | disclosed |
| CN-100562529-C | Curable sealant composition | BRIDGESTONE CORP (JP) | 2009-11-25 | — | — | CN | disclosed |
| US-7608664-B2 | Curable sealant composition and method for manufacturing same | BRIDGESTONE CORPORATION (JP) | 2009-10-27 | — | — | US | disclosed |
| US-3993847-A | RUBBER BONDED TO FERROUS METAL, INTERPOLYMER OF CONJUGATED DIENE AND HETEROCYCLIC NITROGEN BASE | HONNY CHEMICALS COMPANY, LTD. (JA) | 1976-11-23 | — | — | US | disclosed |
| US-3977923-A | Method and solid propellant with unsaturated aziridine cured binder | THE GENERAL TIRE & RUBBER COMPANY (US) | 1976-08-31 | — | — | US | disclosed |
| US-3940353-A | Pigment dispersions and lacquers containing copolymer of isobornyl methacrylate | ROHM AND HAAS COMPANY (US) | 1976-02-24 | — | — | US | disclosed |
| US-RE28682-E | Decorative laminate | ROHM & HAAS COMPANY (US) | 1976-01-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11807624-B2 | Substituted pyrimidinones as agonists of the APJ receptor | APLNR, AGTR1, AGTR2 | HDAC8 3907/4885PTGS2 632/4885GRM5 310/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.