Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 | P00734 | 18/20 | 0.39 |
| ▸ | PRSS1 | P07477 | 9/20 | 0.38 |
| ▸ | PRSS2 | P07478 | 3/20 | 0.38 |
| ▸ | PRSS3 | P35030 | 3/20 | 0.38 |
| ▸ | F10 | P00742 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4026959 | 0.81 | ERCC1 (0.51) | F2PRSS1PRSS2PRSS3ALDH1A1 | |
| SCHEMBL4026962 | 0.79 | F2 (0.39) | F2PRSS1PRSS2PRSS3ALDH1A1 | |
| SCHEMBL4028309 | 0.77 | ALDH1A1 (0.34) | ALDH1A1MAPT | |
| SCHEMBL6620304 | 0.74 | ERCC1 (0.53) | — | |
| SCHEMBL4028108 | 0.74 | ALDH1A1 (0.35) | ALDH1A1MAPT | |
| SCHEMBL6631262 | 0.71 | SMN1; SMN2 (0.33) | ALDH1A1 | |
| SCHEMBL4027808 | 0.70 | DHFR (0.31) | — | |
| SCHEMBL4029058 | 0.68 | ERCC1 (0.36) | ALDH1A1MAPT | |
| SCHEMBL4028095 | 0.67 | GABRP (0.32) | ALDH1A1MAPT | |
| SCHEMBL4033336 | 0.67 | ACKR3 (0.39) | ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1470113-B1 | PYRIMIDINONE VIRAL POLYMERASE INHIBITORS | ANGELETTI P IST RICHERCHE BIO (IT) | 2009-01-07 | — | — | EP | disclosed |
| US-20050130997-A1 | Pyrimidinone viral polymerase inhibitors | ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI SPA (IT) | 2005-06-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050130997-A1 | Pyrimidinone viral polymerase inhibitors | POLR2A, POLR1E, POLR2E | F2 639/4885PRSS1 96/4885PRSS2 400/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.