Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM4 | P08173 | 1/20 | 0.43 |
| ▸ | GPR52 | Q9Y2T5 | 6/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | SCD | O00767 | 2/20 | 0.42 |
| ▸ | DPP4 | P27487 | 2/20 | 0.41 |
| ▸ | HTR1A | P08908 | 2/20 | 0.40 |
| ▸ | CDC7 | O00311 | 1/20 | 0.40 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.40 |
| ▸ | CDK2 | P24941 | 1/20 | 0.40 |
| ▸ | DBF4 | Q9UBU7 | 1/20 | 0.40 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.39 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.39 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.39 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | IKBKB | O14920 | 1/20 | 0.38 |
| ▸ | GSK3B | P49841 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27929449 | 0.81 | SCD (0.53) | GPR52CYP1A2CYP3A4CYP2C19LMNA | |
| SCHEMBL4030637 | 0.81 | GPR52 (0.47) | CHRM4GPR52CYP1A2CYP3A4CYP2C19 | |
| SCHEMBL4032013 | 0.72 | KLKB1 (0.56) | GPR52CYP1A2CYP3A4CYP2C19LMNA | |
| SCHEMBL347832 | 0.72 | SCD (0.74) | SCDHTR1A | |
| SCHEMBL26011296 | 0.69 | LMNA (0.42) | CYP1A2CYP3A4CYP2C19LMNASCD | |
| SCHEMBL18542001 | 0.69 | RAB9A (0.43) | CHRM4CYP1A2CYP2C19RAB9A | |
| SCHEMBL18320904 | 0.69 | SMN1; SMN2 (0.55) | RAB9A | |
| SCHEMBL14108643 | 0.68 | SMN1; SMN2 (0.51) | CHRM4SCDRAB9A | |
| SCHEMBL3717542 | 0.67 | CYP1A2 (0.61) | CYP1A2CYP3A4CYP2C19LMNACDC7 | |
| SCHEMBL18542004 | 0.67 | TSHR (0.56) | CYP1A2CYP2C19RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2054408-A2 | HETEROCYCLIC COMPOUNDS SUITABLE FOR THE TREATMENT OF DISEASES RELATED TO ELEVATED LIPID LEVEL | Novartis Ag (CH) | 2009-05-06 | — | — | EP | disclosed |
| WO-2008127349-A2 | HETEROCYCLIC COMPOUNDS SUITABLE FOR THE TREATMENT OF DISEASES RELATED TO ELEVATED LIPID LEVEL | NOVARTIS AG (CH) | 2008-10-23 | — | — | WO | disclosed |