Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | EEF2K | O00418 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 3/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | CCR3 | P51677 | 2/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.35 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.35 |
| ▸ | MGAT2 | Q10469 | 1/20 | 0.35 |
| ▸ | PPIA | P62937 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4040634 | 0.86 | BCHE (0.44) | KMT2AALDH1A1GAACCR3 | |
| SCHEMBL4035232 | 0.80 | FAAH (0.39) | ALDH1A1RAB9ACCR3KDM4EGRIN2B | |
| SCHEMBL4034612 | 0.78 | ATM (0.40) | KMT2AALDH1A1MEN1POLBKDM4E | |
| SCHEMBL4036671 | 0.77 | SMN1; SMN2 (0.35) | KMT2AALDH1A1MEN1GAASMN1; SMN2 | |
| SCHEMBL4034807 | 0.77 | CXCR3 (0.39) | KMT2AALDH1A1MEN1GAAHTT | |
| SCHEMBL4038442 | 0.75 | KMT2A (0.38) | KMT2AALDH1A1MEN1SMN1; SMN2POLB | |
| SCHEMBL4034900 | 0.75 | CXCR3 (0.40) | ALDH1A1GAAHTTL3MBTL1POLB | |
| SCHEMBL4035453 | 0.74 | BCHE (0.47) | KMT2AALDH1A1MEN1GAAHTT | |
| SCHEMBL1799019 | 0.73 | RIPK1 (0.47) | KMT2AHTTSMN1; SMN2POLBNPSR1 | |
| Hydrochloric Acid SCHEMBL1799641 | 0.72 | RIPK1 (0.46) | KMT2AHTTSMN1; SMN2POLBNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1730144-B1 | SUBSTITUTED 1,4,8-TRIAZASPIRO¬4.5 DECAN-2-ONE COMPOUNDS | GRUENENTHAL GMBH (DE) | 2009-06-10 | — | — | EP | claimed |
| EP-1730144-B1 | SUBSTITUTED 1,4,8-TRIAZASPIRO¬4.5 DECAN-2-ONE COMPOUNDS | GRUENENTHAL GMBH (DE) | 2009-06-10 | — | — | EP | disclosed |