Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.35 |
| ▸ | MAPT | P10636 | 4/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
| ▸ | CCR1 | P32246 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | IGF1R | P08069 | 1/20 | 0.34 |
| ▸ | CA12 | O43570 | 1/20 | 0.34 |
| ▸ | CA1 | P00915 | 1/20 | 0.34 |
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
| ▸ | CA9 | Q16790 | 1/20 | 0.34 |
| ▸ | PTGDR | Q13258 | 3/20 | 0.33 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.33 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.33 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4040157 | 0.87 | MAPT (0.39) | SMN1; SMN2MAPTLMNAHTTKMT2A | |
| SCHEMBL4039234 | 0.87 | MAPT (0.39) | SMN1; SMN2MAPTLMNAHTTKMT2A | |
| SCHEMBL4203707 | 0.74 | ALDH1A1 (0.42) | SMN1; SMN2MAPTLMNAHTTGAA | |
| SCHEMBL4035688 | 0.66 | CA12 (0.39) | THRBCA12CA1CA2CA9 | |
| SCHEMBL4037368 | 0.65 | CCR1 (0.39) | SMN1; SMN2LMNAHTTKMT2AMEN1 | |
| SCHEMBL14015983 | 0.58 | ADRB1 (0.48) | SMN1; SMN2MAPTLMNAHTTKMT2A | |
| SCHEMBL2114232 | 0.57 | ADRB1 (0.49) | MAPTHTTCCR1 | |
| SCHEMBL2115330 | 0.57 | ADRB1 (0.69) | — | |
| SCHEMBL5235809 | 0.57 | MAPT (0.44) | THRBSMN1; SMN2MAPTLMNAHTT | |
| SCHEMBL5045696 | 0.56 | IGF1R (0.43) | THRBSMN1; SMN2MAPTLMNAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1592389-B1 | PIPERAZINE-2-CARBOXAMIDE DERIVATIVES | SERONO LAB (CH) | 2009-04-22 | — | — | EP | claimed |