Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.42 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.42 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.40 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.39 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.39 |
| ▸ | CHUK | O15111 | 7/20 | 0.39 |
| ▸ | ICOSLG | O75144 | 2/20 | 0.37 |
| ▸ | ICOS | Q9Y6W8 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.37 |
| ▸ | TUBB | P07437 | 1/20 | 0.37 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.37 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.37 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.37 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.37 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.37 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.37 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.37 |
| ▸ | TUBA3E | Q6PEY2 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4043016 | 0.87 | ROCK2 (0.40) | ROCK2CHUKICOSLGICOSTUBB4A | |
| SCHEMBL4038757 | 0.87 | MAP2 (0.46) | ROCK2CHUKICOSLGICOSALDH1A1 | |
| SCHEMBL4042867 | 0.85 | TUBB4A (0.46) | ROCK2CHUKICOSLGICOSTUBB4A | |
| SCHEMBL2050145 | 0.84 | MAP2 (0.49) | CSNK2A2CSNK2BROCK2PDE4BENPP2 | |
| SCHEMBL4036827 | 0.80 | KDM4E (0.43) | PDE4BENPP2ALDH1A1TUBB4ATUBB | |
| SCHEMBL4035604 | 0.79 | ACHE (0.40) | ROCK2CHUKTUBB4ATUBBTUBA3C | |
| SCHEMBL4042268 | 0.78 | ICAM1 (0.36) | CHUKRHEB | |
| SCHEMBL4039379 | 0.78 | CHUK (0.42) | ROCK2CHUKICOSLGICOSALDH1A1 | |
| SCHEMBL4040089 | 0.78 | TUBB4A (0.41) | CHUKALDH1A1LMNATUBB4ATUBB | |
| SCHEMBL3269919 | 0.76 | PDE4B (0.38) | PDE4BENPP2TUBB4ATUBBTUBA3C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1747220-B1 | SUBSTITUTED 1H-PYRROLO[3,2-B, 3,2-C, AND 2,3-C]PYRIDINE-2-CARBOXAMIDES AND RELATED ANALOGS AS INHIBITORS OF CASEIN KINASE I EPSILON | AVENTIS PHARMA INC (US) | 2009-04-15 | — | — | EP | claimed |