Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ICAM1 | P05362 | 1/20 | 0.36 |
| ▸ | SELE | P16581 | 1/20 | 0.36 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | RHEB | Q15382 | 1/20 | 0.34 |
| ▸ | CHUK | O15111 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4040089 | 0.88 | TUBB4A (0.41) | ICAM1SELEMEN1KMT2ACHUK | |
| SCHEMBL4035604 | 0.80 | ACHE (0.40) | CHUK | |
| SCHEMBL4038757 | 0.79 | MAP2 (0.46) | ICAM1SELEMEN1KMT2ACHUK | |
| SCHEMBL4035359 | 0.78 | CSNK2A2 (0.42) | RHEBCHUK | |
| SCHEMBL4035489 | 0.77 | SLC6A4 (0.43) | CHEK2MEN1KMT2ARHEB | |
| SCHEMBL6529434 | 0.75 | IDO1 (0.47) | MEN1KMT2ACHUK | |
| SCHEMBL3267982 | 0.74 | MEN1 (0.34) | CHEK2MEN1KMT2ARHEBTP53 | |
| SCHEMBL3835279 | 0.72 | TUBB4A (0.56) | MEN1KMT2A | |
| SCHEMBL4043016 | 0.71 | ROCK2 (0.40) | CHUKTP53 | |
| SCHEMBL6531139 | 0.70 | IDO1 (0.43) | MEN1KMT2ACHUK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1747220-B1 | SUBSTITUTED 1H-PYRROLO[3,2-B, 3,2-C, AND 2,3-C]PYRIDINE-2-CARBOXAMIDES AND RELATED ANALOGS AS INHIBITORS OF CASEIN KINASE I EPSILON | AVENTIS PHARMA INC (US) | 2009-04-15 | — | — | EP | claimed |