Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 2/20 | 0.40 |
| ▸ | CHUK | O15111 | 3/20 | 0.39 |
| ▸ | MAP2 | P11137 | 1/20 | 0.37 |
| ▸ | CDC7 | O00311 | 2/20 | 0.36 |
| ▸ | TYMS | P04818 | 1/20 | 0.36 |
| ▸ | HAO1 | Q9UJM8 | 1/20 | 0.35 |
| ▸ | KDM5A | P29375 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | KDM4C | Q9H3R0 | 4/20 | 0.33 |
| ▸ | ICOSLG | O75144 | 1/20 | 0.33 |
| ▸ | ICOS | Q9Y6W8 | 1/20 | 0.33 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.33 |
| ▸ | CLK2 | P49760 | 2/20 | 0.33 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.33 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.33 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.33 |
| ▸ | KDM6B | O15054 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4035604 | 0.92 | ACHE (0.40) | ROCK2CHUKCDC7TYMSHAO1 | |
| SCHEMBL4035359 | 0.87 | CSNK2A2 (0.42) | ROCK2CHUKMAP2TYMSICOSLG | |
| SCHEMBL4038757 | 0.87 | MAP2 (0.46) | ROCK2CHUKMAP2KDM5ASMN1; SMN2 | |
| SCHEMBL3839280 | 0.85 | TUBB4A (0.44) | TYMSEPHX1POLBTUBB4ATUBB | |
| SCHEMBL4042867 | 0.85 | TUBB4A (0.46) | ROCK2CHUKCDC7ICOSLGICOS | |
| SCHEMBL2049223 | 0.84 | MAP2 (0.49) | ROCK2CHUKMAP2CDC7TYMS | |
| SCHEMBL4035517 | 0.80 | TYMS (0.37) | CDC7TYMSHAO1RAB9AEPHX1 | |
| SCHEMBL4039379 | 0.78 | CHUK (0.42) | ROCK2CHUKMAP2KDM5ASMN1; SMN2 | |
| SCHEMBL4040089 | 0.78 | TUBB4A (0.41) | CHUKMAP2SMN1; SMN2TUBB4ATUBB | |
| SCHEMBL4036022 | 0.77 | MAP2 (0.39) | ROCK2CHUKMAP2KDM5ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1747220-B1 | SUBSTITUTED 1H-PYRROLO[3,2-B, 3,2-C, AND 2,3-C]PYRIDINE-2-CARBOXAMIDES AND RELATED ANALOGS AS INHIBITORS OF CASEIN KINASE I EPSILON | AVENTIS PHARMA INC (US) | 2009-04-15 | — | — | EP | claimed |