Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 1/20 | 0.40 |
| ▸ | CDC7 | O00311 | 2/20 | 0.36 |
| ▸ | TYMS | P04818 | 1/20 | 0.36 |
| ▸ | JAK2 | O60674 | 1/20 | 0.36 |
| ▸ | HAO1 | Q9UJM8 | 1/20 | 0.35 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.34 |
| ▸ | CHUK | O15111 | 1/20 | 0.34 |
| ▸ | KDM4C | Q9H3R0 | 4/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.33 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.33 |
| ▸ | TUBB4A | P04350 | 2/20 | 0.33 |
| ▸ | TUBB | P07437 | 2/20 | 0.33 |
| ▸ | TUBA3C | P0DPH7 | 2/20 | 0.33 |
| ▸ | TUBA1B | P68363 | 2/20 | 0.33 |
| ▸ | TUBA4A | P68366 | 2/20 | 0.33 |
| ▸ | TUBB4B | P68371 | 2/20 | 0.33 |
| ▸ | TUBB3 | Q13509 | 2/20 | 0.33 |
| ▸ | TUBB2A | Q13885 | 2/20 | 0.33 |
| ▸ | TUBB8 | Q3ZCM7 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4043016 | 0.92 | ROCK2 (0.40) | CDC7TYMSHAO1ROCK2CHUK | |
| SCHEMBL4040089 | 0.87 | TUBB4A (0.41) | ACHEJAK2CHUKMAPTTUBB4A | |
| SCHEMBL3839280 | 0.85 | TUBB4A (0.44) | TYMSMAPTEPHX1TUBB4ATUBB | |
| SCHEMBL4042268 | 0.80 | ICAM1 (0.36) | CHUK | |
| SCHEMBL4035517 | 0.80 | TYMS (0.37) | CDC7TYMSJAK2HAO1MAPK14 | |
| SCHEMBL4035359 | 0.79 | CSNK2A2 (0.42) | TYMSROCK2CHUKTUBB4ATUBB | |
| SCHEMBL4038757 | 0.78 | MAP2 (0.46) | ROCK2CHUKMAPTTUBB4ATUBB | |
| SCHEMBL4042867 | 0.77 | TUBB4A (0.46) | CDC7JAK2ROCK2CHUKTUBB4A | |
| SCHEMBL1827677 | 0.77 | POLB (0.42) | TYMSTUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL3269989 | 0.76 | KDR (0.39) | TYMSHAO1MAPTEPHX1TUBB4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1747220-B1 | SUBSTITUTED 1H-PYRROLO[3,2-B, 3,2-C, AND 2,3-C]PYRIDINE-2-CARBOXAMIDES AND RELATED ANALOGS AS INHIBITORS OF CASEIN KINASE I EPSILON | AVENTIS PHARMA INC (US) | 2009-04-15 | — | — | EP | claimed |