Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | HTT | P42858 | 2/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | UHRF1 | Q96T88 | 1/20 | 0.32 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.32 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.32 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.32 |
| ▸ | SLC22A3 | O75751 | 1/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL4035925 | 0.98 | KDM4E (0.32) | KDM4EHTTSMN1; SMN2NPC1MAPK1 | |
| Dimethylamine SCHEMBL10340039 | 0.90 | HDAC8 (0.33) | KDM4EHTTSMN1; SMN2HDAC8SLC22A2 | |
| SCHEMBL6151660 | 0.82 | CYP3A4 (0.40) | KDM4ESMN1; SMN2NPC1RAB9AALDH1A1 | |
| SCHEMBL6152165 | 0.71 | ALDH1A1 (0.43) | KDM4ESMN1; SMN2NPC1ALDH1A1TSHR | |
| SCHEMBL25724553 | 0.71 | RAB9A (0.33) | SMN1; SMN2NPC1RAB9AHDAC8MEN1 | |
| Hydrochloric Acid SCHEMBL585916 | 0.70 | HDAC8 (0.39) | KDM4ESMN1; SMN2NPC1RAB9AHDAC8 | |
| SCHEMBL1164410 | 0.67 | — | — | |
| Hydrochloric Acid SCHEMBL5604381 | 0.67 | SLC22A2 (0.46) | KDM4EHTTSMN1; SMN2NPC1MAPK1 | |
| Hydrochloric Acid SCHEMBL5688232 | 0.67 | CALM1 (0.39) | KDM4ESMN1; SMN2ALDH1A1MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL29098366 | 0.65 | HDAC8 (0.35) | KDM4EHDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2010135-A1 | USE FOR THE DYEING WITH LIGHTENING EFFECT OF KERATIN SUBSTANCES OF A COMPOSITION COMPRISING A FLUORESCENT CYANINE DYE | L'Oréal (FR) | 2009-01-07 | — | — | EP | claimed |
| WO-2007080183-A1 | USE FOR THE DYEING WITH LIGHTENING EFFECT OF KERATIN SUBSTANCES OF A COMPOSITION COMPRISING A FLUORESCENT CYANINE DYE | L'ORÉAL (FR) | 2007-07-19 | — | — | WO | claimed |