Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2 | P11137 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | KIF11 | P52732 | 1/20 | 0.35 |
| ▸ | CHUK | O15111 | 3/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | GABRP | O00591 | 1/20 | 0.35 |
| ▸ | GABRD | O14764 | 1/20 | 0.35 |
| ▸ | IKBKB | O14920 | 1/20 | 0.35 |
| ▸ | AURKA | O14965 | 1/20 | 0.35 |
| ▸ | PIM1 | P11309 | 1/20 | 0.35 |
| ▸ | TOP1 | P11387 | 1/20 | 0.35 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.35 |
| ▸ | IDO1 | P14902 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.35 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.35 |
| ▸ | MAOA | P21397 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4043021 | 0.88 | MAP2 (0.38) | MAP2MAPK1KIF11CHUKKDM4E | |
| SCHEMBL2052333 | 0.84 | MAP2 (0.52) | MAP2LMNAMAPK1KIF11CHUK | |
| SCHEMBL4038766 | 0.83 | TUBB4A (0.45) | MAP2CHUKKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL4038757 | 0.82 | MAP2 (0.46) | MAP2LMNACHUKKDM4EALDH1A1 | |
| SCHEMBL4039379 | 0.80 | CHUK (0.42) | MAP2CHUKKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL4038003 | 0.80 | PARP1 (0.39) | LMNAKIF11KDM4EPARP1RBP4 | |
| SCHEMBL3270325 | 0.77 | KDM4E (0.35) | LMNAKDM4EALDH1A1HPGDPARP1 | |
| SCHEMBL4043016 | 0.77 | ROCK2 (0.40) | MAP2CHUKSMN1; SMN2PIM1KDM5A | |
| SCHEMBL4035359 | 0.74 | CSNK2A2 (0.42) | MAP2LMNACHUKALDH1A1ICOSLG | |
| SCHEMBL4042867 | 0.73 | TUBB4A (0.46) | CHUKICOSLGICOSROCK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1747220-B1 | SUBSTITUTED 1H-PYRROLO[3,2-B, 3,2-C, AND 2,3-C]PYRIDINE-2-CARBOXAMIDES AND RELATED ANALOGS AS INHIBITORS OF CASEIN KINASE I EPSILON | AVENTIS PHARMA INC (US) | 2009-04-15 | — | — | EP | claimed |