Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 7/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 7/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.49 |
| ▸ | RAB9A | P51151 | 5/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.49 |
| ▸ | NPC1 | O15118 | 3/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.49 |
| ▸ | THRB | P10828 | 2/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.49 |
| ▸ | PPARG | P37231 | 1/20 | 0.49 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.49 |
| ▸ | IMPDH2 | P12268 | 2/20 | 0.49 |
| ▸ | CLK1 | P49759 | 1/20 | 0.48 |
| ▸ | GSK3B | P49841 | 1/20 | 0.48 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.48 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27695699 | 0.75 | CLK1 (0.53) | MEN1KMT2AHTTMAPTSMN1; SMN2 | |
| SCHEMBL5084446 | 0.74 | KIF11 (0.45) | MEN1KMT2AMAPTALDH1A1KDM4E | |
| SCHEMBL20562205 | 0.73 | MEN1 (0.56) | MEN1KMT2AHTTMAPTSMN1; SMN2 | |
| SCHEMBL1202543 | 0.73 | IMPDH2 (0.63) | MEN1KMT2AHTTMAPTSMN1; SMN2 | |
| SCHEMBL25034150 | 0.73 | TUBB4A (0.68) | MEN1KMT2AHTTMAPTSMN1; SMN2 | |
| SCHEMBL20017671 | 0.73 | CLK1 (0.58) | MEN1KMT2AHTTMAPTSMN1; SMN2 | |
| SCHEMBL469693 | 0.72 | MEN1 (0.57) | MEN1KMT2AHTTMAPTSMN1; SMN2 | |
| SCHEMBL28399449 | 0.72 | MEN1 (0.65) | MEN1KMT2AHTTMAPTSMN1; SMN2 | |
| SCHEMBL8559737 | 0.72 | MAPT (0.51) | MEN1KMT2AHTTMAPTSMN1; SMN2 | |
| SCHEMBL6428705 | 0.72 | MAPT (0.51) | MEN1KMT2AHTTMAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 55 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220257569-A1 | INDOLE-OXADIAZOLE COMPOUNDS AND THEIR THERAPEUTIC USE | THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO (CA) | 2022-08-18 | — | — | US | disclosed |
| US-20220257569-A1 | INDOLE-OXADIAZOLE COMPOUNDS AND THEIR THERAPEUTIC USE | THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO (CA) | 2022-08-18 | — | — | US | disclosed |
| CN-113214238-B | Preparation and application of indole oxadiazole derivative with acylated piperazine structure | 济南大学 | 2022-07-22 | — | — | CN | disclosed |
| CN-113214238-B | Preparation and application of indole oxadiazole derivative with acylated piperazine structure | 济南大学 | 2022-07-22 | — | — | CN | disclosed |
| CN-113200971-B | Synthesis and application of indole oxadiazole derivative with aryl piperazine structure | 济南大学 | 2022-06-28 | — | — | CN | disclosed |
| CN-113200971-B | Synthesis and application of indole oxadiazole derivative with aryl piperazine structure | 济南大学 | 2022-06-28 | — | — | CN | disclosed |
| CN-113214238-A | Preparation and application of indole oxadiazole derivative with acylated piperazine structure | 济南大学 | 2021-08-06 | — | — | CN | disclosed |
| CN-113214238-A | Preparation and application of indole oxadiazole derivative with acylated piperazine structure | 济南大学 | 2021-08-06 | — | — | CN | disclosed |
| CN-113200971-A | Synthesis and application of indole oxadiazole derivative with aromatic piperazine structure | 济南大学 | 2021-08-03 | — | — | CN | disclosed |
| CN-113200971-A | Synthesis and application of indole oxadiazole derivative with aromatic piperazine structure | 济南大学 | 2021-08-03 | — | — | CN | disclosed |
| US-20100113528-A1 | OXADIAZOLE SUBSTITUTED INDAZOLE DERIVATIVES FOR USE AS SPHINGOSINE 1-PHOSPHATE (S1P) AGONISTS | GLAXO GROUP LIMITED | 2010-05-06 | — | — | US | disclosed |
| US-20100113796-A1 | INDOLE DERIVATIVES AS S1P1 RECEPTOR | GLAXO GROUP LIMITED | 2010-05-06 | — | — | US | disclosed |
| US-20100029729-A1 | COMPOUNDS | GLAXO GROUP LIMITED (GB) | 2010-02-04 | — | — | US | disclosed |
| US-20100010053-A1 | COMPOUNDS | GLAXO GROUP LIMITED (GB) | 2010-01-14 | — | — | US | disclosed |
| EP-2137181-A1 | OXADIAZOLE SUBSTITUTED INDAZOLE DERIVATIVES FOR USE AS SPHINGOSINE 1-PHOSPHATE (S1P) AGONISTS | Glaxo Group Limited (GB) | 2009-12-30 | — | — | EP | disclosed |
| WO-2009153307-A1 | COMPOUNDS | GLAXO GROUP LIMITED (GB) | 2009-12-23 | — | — | WO | disclosed |
| WO-2009133136-A1 | COMPOUNDS | GLAXO GROUP LIMITED (GB) | 2009-11-05 | — | — | WO | disclosed |
| EP-2091949-A1 | INDOLE DERIVATIVES AS S1P1 RECEPTOR AGONISTS | Glaxo Group Limited (GB) | 2009-08-26 | — | — | EP | disclosed |
| WO-2008128951-A1 | OXADIAZOLE SUBSTITUTED INDAZOLE DERIVATIVES FOR USE AS SPHINGOSINE 1-PHOSPHATE (S1P) AGONISTS | GLAXO GROUP LIMITED (GB) | 2008-10-30 | — | — | WO | disclosed |
| WO-2008074821-A1 | INDOLE DERIVATIVES AS S1P1 RECEPTOR AGONISTS | GLAXO GROUP LIMITED (GB) | 2008-06-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100113796-A1 | INDOLE DERIVATIVES AS S1P1 RECEPTOR | S1PR1, S1PR3, S1PR2 | MEN1 731/4885KMT2A 2344/4885HTT 2153/4885 |
| US-20100029729-A1 | COMPOUNDS | CYP11B2, CYP11B1, GLS2 | MEN1 2901/4885KMT2A 4598/4885HTT 1267/4885 |
| US-20100010053-A1 | COMPOUNDS | CYP11B2, CYP11B1, GLS2 | MEN1 2901/4885KMT2A 4598/4885HTT 1267/4885 |
| US-20220257569-A1 | INDOLE-OXADIAZOLE COMPOUNDS AND THEIR THERAPEUTIC USE | CNR2, GPR119, CNR1 | MEN1 4146/4885KMT2A 2952/4885HTT 3755/4885 |
| US-20100113528-A1 | OXADIAZOLE SUBSTITUTED INDAZOLE DERIVATIVES FOR USE AS SPHINGOSINE 1-PHOSPHATE (S1P) AGONISTS | S1PR1, S1PR3, S1PR2 | MEN1 2012/4885KMT2A 4115/4885HTT 4717/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.