Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.49 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.49 |
| ▸ | BRS3 | P32247 | 1/20 | 0.48 |
| ▸ | MMP13 | P45452 | 7/20 | 0.48 |
| ▸ | APEX1 | P27695 | 1/20 | 0.47 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | PARP1 | P09874 | 1/20 | 0.46 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.46 |
| ▸ | ALPL | P05186 | 2/20 | 0.45 |
| ▸ | PDE5A | O76074 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL403861 | 0.86 | RNASEH1 (0.51) | APEX1PARP1PARP2 | |
| SCHEMBL405606 | 0.85 | KMT2A (0.61) | PARP1PARP2PDE5A | |
| SCHEMBL401142 | 0.83 | PDE5A (0.64) | BRS3HCAR2PARP1PARP2PDE5A | |
| SCHEMBL400190 | 0.83 | KDM4C (0.52) | KDM4CKDM5BBRS3MMP13 | |
| SCHEMBL402059 | 0.80 | PDE5A (0.61) | KDM4CKDM5BMMP13PDE5A | |
| SCHEMBL404377 | 0.80 | RNASEH1 (0.60) | KDM5BAPEX1PARP1PARP2PDE5A | |
| SCHEMBL401645 | 0.80 | PDE5A (0.72) | KDM4CKDM5BMMP13PDE5A | |
| SCHEMBL403274 | 0.79 | ALOX15 (0.50) | BRS3HCAR2PARP1PARP2 | |
| SCHEMBL403048 | 0.79 | ALDH1A1 (0.48) | PARP1PARP2PDE5A | |
| SCHEMBL17888978 | 0.77 | MMP13 (0.58) | MMP13PDE5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2050739-B1 | QUINAZOLINE DERIVATIVE | ASKA PHARM CO LTD (JP) | 2016-07-06 | — | — | EP | disclosed |
| CN-101501007-B | Quinazoline derivative | ASKA PARMACEUTICAL CO LTD | 2014-01-29 | — | — | CN | disclosed |
| US-8101624-B2 | Quinazoline derivatives | ASKA PHARMACEUTICAL CO., LTD. (JP) | 2012-01-24 | — | — | US | disclosed |
| US-20100113484-A1 | TREATING AGENT OF UROPATHY | ASKA PHARMACEUTICAL CO., LTD. (JP) | 2010-05-06 | — | — | US | disclosed |
| US-20090318478-A1 | QUINAZOLINE DERIVATIVES | ASKA PHARMACEUTICAL CO., LTD. | 2009-12-24 | — | — | US | disclosed |
| EP-2123301-A1 | THERAPEUTIC AGENT FOR URINARY TRACT DISEASE | ASKA Pharmaceutical Co., Ltd. (JP) | 2009-11-25 | — | — | EP | disclosed |
| CN-101557826-A | Therapeutic agent for urinary tract disease | ASKA PHARM CO LTD (JP) | 2009-10-14 | — | — | CN | disclosed |
| CN-101501007-A | Quinazoline derivative | ASKA PARMACEUTICAL CO LTD (JP) | 2009-08-05 | — | — | CN | disclosed |
| EP-2050739-A1 | QUINAZOLINE DERIVATIVE | ASKA Pharmaceutical Co., Ltd. (JP) | 2009-04-22 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100113484-A1 | TREATING AGENT OF UROPATHY | BPHL, PDE12, UROD | KDM4C 4042/4885KDM5B 2650/4885BRS3 3332/4885 |
| US-20090318478-A1 | QUINAZOLINE DERIVATIVES | PDE9A, PDE3A, PDE5A | KDM4C 2461/4885KDM5B 1954/4885BRS3 806/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.