Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | PREP | P48147 | 2/20 | 0.35 |
| ▸ | FAP | Q12884 | 2/20 | 0.35 |
| ▸ | CTSK | P43235 | 4/20 | 0.33 |
| ▸ | NR2F2 | P24468 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | PPARG | P37231 | 1/20 | 0.33 |
| ▸ | PPARA | Q07869 | 1/20 | 0.33 |
| ▸ | ELANE | P08246 | 1/20 | 0.32 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.32 |
| ▸ | ITGB2 | P05107 | 2/20 | 0.32 |
| ▸ | ICAM1 | P05362 | 2/20 | 0.32 |
| ▸ | ITGAL | P20701 | 2/20 | 0.32 |
| ▸ | CTSL | P07711 | 1/20 | 0.32 |
| ▸ | CTSB | P07858 | 1/20 | 0.32 |
| ▸ | CTSS | P25774 | 1/20 | 0.32 |
| ▸ | GALR3 | O60755 | 1/20 | 0.31 |
| ▸ | ATM | Q13315 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4045026 | 0.95 | CTSK (0.36) | ALDH1A1PREPFAPCTSKELANE | |
| SCHEMBL4041598 | 0.93 | CTSK (0.40) | ALDH1A1CTSKELANECTSLCTSB | |
| SCHEMBL4046799 | 0.90 | ALDH1A1 (0.39) | ALDH1A1PREPFAPCTSKCTSL | |
| SCHEMBL4047431 | 0.90 | ALDH1A1 (0.37) | ALDH1A1PREPFAPNR2F2RAB9A | |
| SCHEMBL4043139 | 0.89 | ELANE (0.37) | ALDH1A1PREPFAPCTSKELANE | |
| SCHEMBL4043678 | 0.88 | ALDH1A1 (0.38) | ALDH1A1PREPFAPCTSKNR2F2 | |
| SCHEMBL4048179 | 0.88 | TSHR (0.36) | ALDH1A1PREPFAPRAB9AELANE | |
| SCHEMBL4051956 | 0.87 | CTSK (0.41) | CTSKELANECTSLCTSBCTSS | |
| SCHEMBL4044622 | 0.87 | CTSK (0.38) | PREPFAPCTSKELANECTSL | |
| SCHEMBL4045022 | 0.87 | CTSK (0.35) | PREPFAPCTSKELANECTSL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1506175-B1 | N-SUBSTITUTED TRICYCLIC 3-AMINOPYRAZOLES AS PDGF RECEPTOR INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2009-04-01 | — | — | EP | disclosed |