Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 5/20 | 0.38 |
| ▸ | CTSL | P07711 | 3/20 | 0.38 |
| ▸ | CTSS | P25774 | 3/20 | 0.38 |
| ▸ | CTSB | P07858 | 1/20 | 0.38 |
| ▸ | PREP | P48147 | 2/20 | 0.36 |
| ▸ | FAP | Q12884 | 2/20 | 0.36 |
| ▸ | ELANE | P08246 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | MC4R | P32245 | 1/20 | 0.31 |
| ▸ | MC3R | P41968 | 1/20 | 0.31 |
| ▸ | MC1R | Q01726 | 1/20 | 0.31 |
| ▸ | REN | P00797 | 1/20 | 0.31 |
| ▸ | CTSD | P07339 | 1/20 | 0.31 |
| ▸ | CTSE | P14091 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | F10 | P00742 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4045950 | 0.93 | CTSK (0.43) | CTSKCTSLCTSSCTSBKMT2A | |
| SCHEMBL4042075 | 0.92 | PREP (0.36) | CTSKCTSLCTSSCTSBPREP | |
| SCHEMBL4044872 | 0.90 | CTSK (0.44) | CTSKCTSLCTSSCTSBPREP | |
| SCHEMBL4045026 | 0.89 | CTSK (0.36) | CTSKCTSLCTSSCTSBPREP | |
| SCHEMBL6236601 | 0.89 | CTSK (0.48) | CTSKCTSLCTSSCTSBPREP | |
| SCHEMBL4046652 | 0.88 | CHRNB2 (0.35) | CTSKCTSLCTSSCTSBPREP | |
| SCHEMBL4052232 | 0.88 | CTSK (0.38) | CTSKCTSLCTSSCTSBPREP | |
| SCHEMBL4039771 | 0.87 | ALDH1A1 (0.38) | CTSKCTSLCTSSCTSBPREP | |
| SCHEMBL4045022 | 0.86 | CTSK (0.35) | CTSKCTSLCTSSCTSBPREP | |
| SCHEMBL4043139 | 0.86 | ELANE (0.37) | CTSKPREPFAPELANEKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1546150-B1 | PYRROLE DERIVATIVES AS INHIBITORS OF CYTEINE PROTEASES | AMURA THERAPEUTICS LTD (GB) | 2009-03-04 | — | — | EP | claimed |