Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 10/20 | 0.39 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.36 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.36 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.35 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.35 |
| ▸ | USP2 | O75604 | 3/20 | 0.35 |
| ▸ | LMNA | P02545 | 3/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.35 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 2/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | CTSL | P07711 | 6/20 | 0.34 |
| ▸ | CTSS | P25774 | 6/20 | 0.34 |
| ▸ | CTSB | P07858 | 3/20 | 0.34 |
| ▸ | CTSV | O60911 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4042714 | 0.93 | SMN1; SMN2 (0.36) | CTSKCHRNB2CHRNA7CHRNA4HSD17B10 | |
| SCHEMBL4047585 | 0.90 | CTSK (0.41) | CTSKCHRNB2CHRNA7CHRNA4CTSL | |
| SCHEMBL4044165 | 0.90 | CTSK (0.38) | CTSKCHRNB2CHRNA7CHRNA4NPSR1 | |
| SCHEMBL4050728 | 0.90 | SMN1; SMN2 (0.33) | CTSKCHRNB2CHRNA7CHRNA4HSD17B10 | |
| SCHEMBL4043622 | 0.89 | CTSK (0.39) | CTSKCTSLCTSSCTSBCTSV | |
| SCHEMBL4048016 | 0.88 | CTSK (0.46) | CTSKCTSLCTSSCTSBCTSV | |
| SCHEMBL4043843 | 0.86 | CTSK (0.41) | CTSKHSD17B10HCRTR2CTSLCTSS | |
| SCHEMBL4050081 | 0.85 | CTSK (0.42) | CTSKCHRNB2CHRNA7CHRNA4GAA | |
| SCHEMBL4049252 | 0.85 | CTSK (0.39) | CTSKCTSLCTSSCTSBCTSV | |
| SCHEMBL4042095 | 0.85 | CTSK (0.39) | CTSKSMN1; SMN2KMT2ACTSLCTSS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1546150-B1 | PYRROLE DERIVATIVES AS INHIBITORS OF CYTEINE PROTEASES | AMURA THERAPEUTICS LTD (GB) | 2009-03-04 | — | — | EP | claimed |