Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 17/20 | 0.39 |
| ▸ | CTSL | P07711 | 15/20 | 0.36 |
| ▸ | CTSS | P25774 | 11/20 | 0.36 |
| ▸ | CTSB | P07858 | 3/20 | 0.36 |
| ▸ | CTSV | O60911 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4040800 | 0.93 | PREP (0.36) | CTSKCTSLCTSSCTSBCTSV | |
| SCHEMBL4047097 | 0.93 | CTSL (0.33) | CTSKCTSLCTSSCTSBCTSV | |
| SCHEMBL4048016 | 0.90 | CTSK (0.46) | CTSKCTSLCTSSCTSBCTSV | |
| SCHEMBL4045248 | 0.90 | NPC1 (0.33) | CTSKCTSLCTSSCTSBCTSV | |
| SCHEMBL4044165 | 0.88 | CTSK (0.38) | CTSKCTSLCTSSCTSBSMN1; SMN2 | |
| SCHEMBL4049252 | 0.88 | CTSK (0.39) | CTSKCTSLCTSSCTSBCTSV | |
| SCHEMBL4051812 | 0.86 | CTSK (0.43) | CTSKCTSLCTSSCTSBCTSV | |
| SCHEMBL4039790 | 0.85 | CTSK (0.39) | CTSKCTSLCTSSCTSBCTSV | |
| SCHEMBL4041529 | 0.84 | CTSK (0.47) | CTSKCTSLCTSSCTSBCTSV | |
| SCHEMBL4050718 | 0.84 | CTSK (0.41) | CTSKCTSLCTSSCTSBCTSV |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2439193-B1 | Derivatives of 5,6-bisaryl-2-pyridine-carboxamide, preparation and use thereof in therapeutics as antagonists of urotensin II receptors | SANOFI SA (FR) | 2014-04-23 | — | — | EP | disclosed |
| EP-2059508-B1 | 5,6-BISARYL-2-PYRIDINE-CARBOXAMIDE DERIVATIVES, PREPARATION AND APPLICATION THEREOF IN THERAPEUTICS AS UROTENSIN II RECEPTOR ANTAGONISTS | SANOFI SA (FR) | 2012-04-11 | — | — | EP | disclosed |
| EP-2059508-A1 | 5,6-BISARYL-2-PYRIDINE-CARBOXAMIDE DERIVATIVES, PREPARATION AND APPLICATION THEREOF IN THERAPEUTICS AS UROTENSIN II RECEPTOR ANTAGONISTS | Sanofi-Aventis (FR) | 2009-05-20 | — | — | EP | disclosed |
| WO-2008020124-A1 | 5,6-BISARYL-2-PYRIDINE-CARBOXAMIDE DERIVATIVES, PREPARATION AND APPLICATION THEREOF IN THERAPEUTICS AS UROTENSIN II RECEPTOR ANTAGONISTS | SANOFI-AVENTIS (FR) | 2008-02-21 | — | — | WO | disclosed |