Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 14/20 | 0.41 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.34 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.34 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.34 |
| ▸ | PREP | P48147 | 2/20 | 0.33 |
| ▸ | FAP | Q12884 | 1/20 | 0.33 |
| ▸ | CTSL | P07711 | 7/20 | 0.32 |
| ▸ | CTSS | P25774 | 7/20 | 0.32 |
| ▸ | CTSB | P07858 | 3/20 | 0.32 |
| ▸ | ELANE | P08246 | 1/20 | 0.32 |
| ▸ | CTSV | O60911 | 1/20 | 0.32 |
| ▸ | MMP1 | P03956 | 1/20 | 0.32 |
| ▸ | MMP3 | P08254 | 1/20 | 0.32 |
| ▸ | MMP9 | P14780 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4046502 | 0.93 | PREP (0.34) | CTSKCHRNB2CHRNA7CHRNA4PREP | |
| SCHEMBL4042994 | 0.93 | CTSS (0.35) | CTSKCHRNB2CHRNA7CHRNA4PREP | |
| SCHEMBL4039790 | 0.90 | CTSK (0.39) | CTSKCHRNB2CHRNA7CHRNA4CTSL | |
| SCHEMBL4042344 | 0.90 | CTSK (0.33) | CTSKCHRNB2CHRNA7CHRNA4 | |
| SCHEMBL4044165 | 0.89 | CTSK (0.38) | CTSKCHRNB2CHRNA7CHRNA4CTSL | |
| SCHEMBL4049252 | 0.88 | CTSK (0.39) | CTSKCTSLCTSSCTSBCTSV | |
| SCHEMBL4045633 | 0.86 | CTSK (0.41) | CTSKPREPFAPCTSLCTSS | |
| SCHEMBL4048016 | 0.85 | CTSK (0.46) | CTSKCTSLCTSSCTSBCTSV | |
| SCHEMBL4045571 | 0.85 | CTSK (0.46) | CTSKCHRNA7PREPFAPCTSL | |
| SCHEMBL4047069 | 0.84 | CTSK (0.42) | CTSKPREPFAPCTSLCTSS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1546150-B1 | PYRROLE DERIVATIVES AS INHIBITORS OF CYTEINE PROTEASES | AMURA THERAPEUTICS LTD (GB) | 2009-03-04 | — | — | EP | claimed |
| EP-2010487-A1 | 5-AMIDO-2-CARBOXAMIDE INDOLES | F. Hoffmann-Roche AG (CH) | 2009-01-07 | — | — | EP | disclosed |
| WO-2007115938-A1 | 5-AMIDO-2-CARBOXAMIDE INDOLES | F. HOFFMANN-LA ROCHE AG (CH) | 2007-10-18 | — | — | WO | disclosed |