Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 7/20 | 0.38 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.38 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.38 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | CTSL | P07711 | 4/20 | 0.34 |
| ▸ | CTSS | P25774 | 3/20 | 0.34 |
| ▸ | CTSB | P07858 | 2/20 | 0.34 |
| ▸ | SMYD3 | Q9H7B4 | 2/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | GLA | P06280 | 1/20 | 0.34 |
| ▸ | USP2 | O75604 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4048128 | 0.93 | CHRNB2 (0.36) | CHRNB2CHRNA7CHRNA4GAASMYD3 | |
| SCHEMBL4049249 | 0.93 | CHRNB2 (0.36) | CHRNB2CHRNA7CHRNA4GAACTSL | |
| SCHEMBL4039790 | 0.90 | CTSK (0.39) | CTSKCHRNB2CHRNA7CHRNA4GAA | |
| SCHEMBL4046215 | 0.90 | CHRNB2 (0.34) | CTSKCHRNB2CHRNA7CHRNA4GAA | |
| SCHEMBL4047585 | 0.89 | CTSK (0.41) | CTSKCHRNB2CHRNA7CHRNA4CTSL | |
| SCHEMBL4042095 | 0.88 | CTSK (0.39) | CTSKCTSLCTSSCTSBSMN1; SMN2 | |
| SCHEMBL4050081 | 0.88 | CTSK (0.42) | CTSKCHRNB2CHRNA7CHRNA4GAA | |
| SCHEMBL4040754 | 0.86 | CTSK (0.40) | CTSKCHRNB2CHRNA7CHRNA4CTSL | |
| SCHEMBL4048016 | 0.85 | CTSK (0.46) | CTSKCTSLCTSSCTSB | |
| SCHEMBL4043952 | 0.85 | CTSK (0.42) | CTSKCHRNA7CTSLCTSSCTSB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1546150-B1 | PYRROLE DERIVATIVES AS INHIBITORS OF CYTEINE PROTEASES | AMURA THERAPEUTICS LTD (GB) | 2009-03-04 | — | — | EP | claimed |