Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSS | P25774 | 7/20 | 0.42 |
| ▸ | CTSL | P07711 | 6/20 | 0.42 |
| ▸ | CTSV | O60911 | 2/20 | 0.42 |
| ▸ | CTSK | P43235 | 7/20 | 0.38 |
| ▸ | F2RL1 | P55085 | 2/20 | 0.35 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.33 |
| ▸ | HTRA1 | Q92743 | 3/20 | 0.33 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.33 |
| ▸ | F12 | P00748 | 1/20 | 0.33 |
| ▸ | PSMB11 | A5LHX3 | 1/20 | 0.32 |
| ▸ | PSMA7 | O14818 | 1/20 | 0.32 |
| ▸ | PSMB1 | P20618 | 1/20 | 0.32 |
| ▸ | PSMA1 | P25786 | 1/20 | 0.32 |
| ▸ | PSMA2 | P25787 | 1/20 | 0.32 |
| ▸ | PSMA3 | P25788 | 1/20 | 0.32 |
| ▸ | PSMA4 | P25789 | 1/20 | 0.32 |
| ▸ | PSMB8 | P28062 | 1/20 | 0.32 |
| ▸ | PSMB9 | P28065 | 1/20 | 0.32 |
| ▸ | PSMA5 | P28066 | 1/20 | 0.32 |
| ▸ | PSMB4 | P28070 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4044026 | 0.89 | CTSK (0.49) | CTSSCTSLCTSK | |
| SCHEMBL4050717 | 0.88 | CTSK (0.44) | CTSSCTSLCTSK | |
| SCHEMBL4049845 | 0.88 | CTSK (0.40) | CTSSCTSLCTSK | |
| SCHEMBL4050085 | 0.88 | CTSS (0.40) | CTSSCTSLCTSVCTSKF2RL1 | |
| SCHEMBL4041473 | 0.88 | CTSS (0.41) | CTSSCTSLCTSVCTSKF2RL1 | |
| SCHEMBL4047616 | 0.86 | CTSL (0.46) | CTSSCTSLCTSVCTSK | |
| SCHEMBL4047634 | 0.83 | CTSL (0.39) | CTSSCTSLCTSVCTSKF2RL1 | |
| SCHEMBL4044772 | 0.82 | CTSV (0.39) | CTSSCTSLCTSVCTSKF2RL1 | |
| SCHEMBL4043817 | 0.80 | CTSL (0.39) | CTSSCTSLCTSVCTSKHTRA1 | |
| SCHEMBL4042558 | 0.79 | CTSK (0.39) | CTSSCTSLCTSVCTSK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1546150-B1 | PYRROLE DERIVATIVES AS INHIBITORS OF CYTEINE PROTEASES | AMURA THERAPEUTICS LTD (GB) | 2009-03-04 | — | — | EP | claimed |