Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSV | O60911 | 2/20 | 0.39 |
| ▸ | CTSL | P07711 | 2/20 | 0.39 |
| ▸ | CTSS | P25774 | 2/20 | 0.39 |
| ▸ | HTRA1 | Q92743 | 2/20 | 0.38 |
| ▸ | GPR132 | Q9UNW8 | 1/20 | 0.38 |
| ▸ | C3AR1 | Q16581 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | F2RL1 | P55085 | 2/20 | 0.33 |
| ▸ | CPB2 | Q96IY4 | 1/20 | 0.33 |
| ▸ | CTSK | P43235 | 2/20 | 0.33 |
| ▸ | FPR2 | P25090 | 1/20 | 0.32 |
| ▸ | F12 | P00748 | 2/20 | 0.32 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.32 |
| ▸ | REN | P00797 | 1/20 | 0.32 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.32 |
| ▸ | NAMPT | P43490 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4050440 | 0.90 | CTSK (0.43) | CTSLCTSSCTSKCHRNA7 | |
| SCHEMBL4050112 | 0.89 | CTSK (0.38) | CTSKHRH3CHRNA7 | |
| SCHEMBL4040981 | 0.89 | CTSK (0.35) | GPR132CTSKHRH3CHRNA7 | |
| SCHEMBL4041667 | 0.88 | HTRA1 (0.38) | CTSVCTSLCTSSHTRA1GPR132 | |
| SCHEMBL4047756 | 0.87 | CTSL (0.38) | CTSVCTSLCTSSHTRA1GPR132 | |
| SCHEMBL4043817 | 0.85 | CTSL (0.39) | CTSVCTSLCTSSHTRA1GPR132 | |
| SCHEMBL4043551 | 0.83 | CTSL (0.41) | CTSVCTSLCTSSHTRA1GPR132 | |
| SCHEMBL4045088 | 0.83 | CTSS (0.37) | CTSVCTSLCTSSHTRA1GPR132 | |
| SCHEMBL4041369 | 0.82 | CTSS (0.42) | CTSVCTSLCTSSHTRA1F2RL1 | |
| SCHEMBL4041842 | 0.79 | CHRNB2 (0.37) | CTSVCTSLCTSSHTRA1CTSK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1546150-B1 | PYRROLE DERIVATIVES AS INHIBITORS OF CYTEINE PROTEASES | AMURA THERAPEUTICS LTD (GB) | 2009-03-04 | — | — | EP | claimed |