Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | CCR5 | P51681 | 2/20 | 0.36 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.35 |
| ▸ | ACE | P12821 | 1/20 | 0.35 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.35 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3925416 | 0.85 | KDM4E (0.36) | KDM4EL3MBTL1TDP1LMNAMEN1 | |
| SCHEMBL3928453 | 0.84 | KDM4E (0.36) | KDM4EGAAL3MBTL1TDP1LMNA | |
| SCHEMBL4037263 | 0.83 | ALDH1A1 (0.32) | — | |
| SCHEMBL4041825 | 0.79 | NPSR1 (0.43) | KDM4EGAACCR5ACETDP1 | |
| SCHEMBL3917023 | 0.79 | KDM4E (0.48) | KDM4EGAATDP1LMNAMEN1 | |
| SCHEMBL2934783 | 0.78 | CCR5 (0.40) | GAACCR5LMNAMEN1KMT2A | |
| SCHEMBL4032393 | 0.78 | SIGMAR1 (0.39) | KDM4EMEN1KMT2ACXCR3 | |
| SCHEMBL2938912 | 0.78 | CYP3A4 (0.42) | KDM4EGAACCR5CYP3A4LMNA | |
| SCHEMBL2932813 | 0.77 | MEN1 (0.43) | KDM4EL3MBTL1LMNAMEN1KMT2A | |
| SCHEMBL2940845 | 0.76 | GRM5 (0.47) | LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1730144-B1 | SUBSTITUTED 1,4,8-TRIAZASPIRO¬4.5 DECAN-2-ONE COMPOUNDS | GRUENENTHAL GMBH (DE) | 2009-06-10 | — | — | EP | claimed |