Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 13/20 | 0.56 |
| ▸ | CTSS | P25774 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 3/20 | 0.38 |
| ▸ | CA12 | O43570 | 2/20 | 0.38 |
| ▸ | CA9 | Q16790 | 2/20 | 0.38 |
| ▸ | PREP | P48147 | 1/20 | 0.35 |
| ▸ | FAP | Q12884 | 1/20 | 0.35 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.35 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.35 |
| ▸ | CCR1 | P32246 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4038867 | 0.93 | CTSK (0.66) | CTSKCTSSCA1CA12CA9 | |
| SCHEMBL4040962 | 0.92 | CTSK (0.64) | CTSKCTSSCA1CA12CA9 | |
| SCHEMBL4039481 | 0.91 | CTSK (0.56) | CTSKCTSSCA1CA12CA9 | |
| SCHEMBL4039382 | 0.90 | CTSK (0.53) | CTSKCTSSCA1CA12CA9 | |
| SCHEMBL4045514 | 0.89 | CTSK (0.55) | CTSKCTSSCA1CA12CA9 | |
| SCHEMBL4045856 | 0.89 | CTSK (0.65) | CTSKCTSSPREPFAPDPP8 | |
| SCHEMBL4039936 | 0.88 | CTSK (0.53) | CTSKCTSSPREPFAPDPP8 | |
| SCHEMBL4040520 | 0.87 | CTSK (0.71) | CTSKCTSSCA1CA12CA9 | |
| SCHEMBL4042243 | 0.87 | CTSK (0.58) | CTSKCTSS | |
| SCHEMBL4045147 | 0.87 | CTSK (0.56) | CTSKCTSSCA1CA12CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1635641-B1 | MITOTIC KINESIN INHIBITORS | MERCK & CO INC (US) | 2009-03-25 | — | — | EP | claimed |
| EP-1546150-B1 | PYRROLE DERIVATIVES AS INHIBITORS OF CYTEINE PROTEASES | AMURA THERAPEUTICS LTD (GB) | 2009-03-04 | — | — | EP | claimed |
| US-7427637-B2 | Mitotic kinesin inhibitors | MERCK & CO. INC. (US) | 2008-09-23 | — | — | US | claimed |
| US-20060142278-A1 | Mitotic kinesin inhibitors | MERCK SHARP & DOHME CORP. | 2006-06-29 | — | — | US | claimed |
| US-20060100431-A1 | Biologically active compounds | AMURA THERAPEUTICS LIMITED (GB) | 2006-05-11 | — | — | US | claimed |
| EP-1635641-B1 | MITOTIC KINESIN INHIBITORS | MERCK & CO INC (US) | 2009-03-25 | — | — | EP | disclosed |
| EP-1546150-B1 | PYRROLE DERIVATIVES AS INHIBITORS OF CYTEINE PROTEASES | AMURA THERAPEUTICS LTD (GB) | 2009-03-04 | — | — | EP | disclosed |
| US-7427637-B2 | Mitotic kinesin inhibitors | MERCK & CO. INC. (US) | 2008-09-23 | — | — | US | disclosed |
| US-20060142278-A1 | Mitotic kinesin inhibitors | MERCK SHARP & DOHME CORP. | 2006-06-29 | — | — | US | disclosed |
| EP-1546150-A1 | BIOLOGICALLY ACTIVE COMPOUNDS | Amura Therapeutics Limited (GB) | 2005-06-29 | — | — | EP | disclosed |
| WO-2004007501-A1 | BIOLOGICALLY ACTIVE COMPOUNDS | AMURA THERAPEUTICS LIMITED (GB) | 2004-01-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060142278-A1 | Mitotic kinesin inhibitors | KIF5B, KIF2C, KIF18A | CTSK 1676/4885CTSS 2293/4885CA1 3634/4885 |
| US-20060100431-A1 | Biologically active compounds | SOST, CTSK, CTSS | CTSK 2/4885CTSS 3/4885CA1 60/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.