Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.42 |
| ▸ | DCTPP1 | Q9H773 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | HTR2B | P41595 | 1/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3918416 | 0.87 | KMT2A (0.46) | KMT2AMEN1RAB9ANR3C1DCTPP1 | |
| SCHEMBL4041475 | 0.86 | MMP2 (0.39) | KMT2AMEN1ALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL3919295 | 0.86 | KMT2A (0.45) | KMT2AMEN1RAB9ANR3C1ALDH1A1 | |
| SCHEMBL3927380 | 0.86 | CYP2D6 (0.45) | KMT2AMEN1ALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL3915518 | 0.85 | KMT2A (0.44) | KMT2AMEN1RAB9ANR3C1DCTPP1 | |
| SCHEMBL4041414 | 0.83 | KMT2A (0.46) | KMT2AMEN1RAB9AALDH1A1LMNA | |
| SCHEMBL3917715 | 0.82 | RAB9A (0.44) | KMT2AMEN1RAB9ANR3C1DCTPP1 | |
| SCHEMBL4037611 | 0.81 | ALDH1A1 (0.53) | KMT2AMEN1RAB9AALDH1A1LMNA | |
| SCHEMBL4038204 | 0.80 | EPHX2 (0.47) | KMT2AMEN1ALDH1A1EPHX2L3MBTL1 | |
| SCHEMBL4041453 | 0.80 | MEN1 (0.42) | KMT2AMEN1ALDH1A1LMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1730144-B1 | SUBSTITUTED 1,4,8-TRIAZASPIRO¬4.5 DECAN-2-ONE COMPOUNDS | GRUENENTHAL GMBH (DE) | 2009-06-10 | — | — | EP | claimed |