Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 9/20 | 0.47 |
| ▸ | EBP | Q15125 | 1/20 | 0.46 |
| ▸ | DHCR7 | Q9UBM7 | 1/20 | 0.46 |
| ▸ | CCR5 | P51681 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4032408 | 0.86 | ALDH1A1 (0.52) | EPHX2ALDH1A1MEN1KMT2ACYP3A4 | |
| SCHEMBL3927380 | 0.86 | CYP2D6 (0.45) | ALDH1A1MEN1KMT2AMAPK1L3MBTL1 | |
| SCHEMBL4041475 | 0.84 | MMP2 (0.39) | ALDH1A1MEN1KMT2AL3MBTL1 | |
| SCHEMBL3916082 | 0.84 | EPHX2 (0.46) | EPHX2EBPDHCR7CCR5ALDH1A1 | |
| SCHEMBL4041414 | 0.83 | KMT2A (0.46) | ALDH1A1MEN1KMT2AMAPK1 | |
| SCHEMBL4037859 | 0.82 | L3MBTL1 (0.48) | EPHX2ALDH1A1MEN1KMT2AL3MBTL1 | |
| SCHEMBL4037858 | 0.82 | L3MBTL1 (0.48) | EPHX2ALDH1A1MEN1KMT2AL3MBTL1 | |
| SCHEMBL4035567 | 0.81 | LMNA (0.48) | ALDH1A1MEN1KMT2ACYP3A4CYP2D6 | |
| SCHEMBL4041277 | 0.81 | KMT2A (0.41) | ALDH1A1MEN1KMT2A | |
| SCHEMBL4037894 | 0.81 | ALDH1A1 (0.54) | CCR5ALDH1A1MEN1KMT2AMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1730144-B1 | SUBSTITUTED 1,4,8-TRIAZASPIRO¬4.5 DECAN-2-ONE COMPOUNDS | GRUENENTHAL GMBH (DE) | 2009-06-10 | — | — | EP | claimed |