Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | NEK2 | P51955 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3927380 | 0.88 | CYP2D6 (0.45) | KMT2ATSHRALDH1A1MAPTGAA | |
| SCHEMBL4037038 | 0.88 | SMN1; SMN2 (0.41) | KMT2ANPSR1MAPTPKMGAA | |
| SCHEMBL4038362 | 0.86 | KMT2A (0.43) | KMT2AHPGDTSHRHSD11B1NPSR1 | |
| SCHEMBL4041475 | 0.85 | MMP2 (0.39) | KMT2ATSHRALDH1A1MAPTGAA | |
| SCHEMBL4037611 | 0.83 | ALDH1A1 (0.53) | KMT2ATSHRALDH1A1MAPTRAB9A | |
| SCHEMBL4038204 | 0.83 | EPHX2 (0.47) | KMT2AALDH1A1MAPK1MEN1 | |
| SCHEMBL4042839 | 0.83 | KMT2A (0.46) | KMT2AALDH1A1RAB9APKMGAA | |
| SCHEMBL4037768 | 0.82 | LMNA (0.54) | KMT2ATSHRNPSR1ALDH1A1GAA | |
| SCHEMBL4035567 | 0.82 | LMNA (0.48) | KMT2ATSHRHSD11B1ALDH1A1MAPT | |
| SCHEMBL4041277 | 0.82 | KMT2A (0.41) | KMT2ATSHRHSD11B1ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1730144-B1 | SUBSTITUTED 1,4,8-TRIAZASPIRO¬4.5 DECAN-2-ONE COMPOUNDS | GRUENENTHAL GMBH (DE) | 2009-06-10 | — | — | EP | claimed |