Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 2/20 | 0.39 |
| ▸ | MMP13 | P45452 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.34 |
| ▸ | ACLY | P53396 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3927380 | 0.88 | CYP2D6 (0.45) | SMN1; SMN2GAAHTTTSHRALDH1A1 | |
| SCHEMBL4042839 | 0.86 | KMT2A (0.46) | SMN1; SMN2GAAALDH1A1L3MBTL1KMT2A | |
| SCHEMBL4041414 | 0.85 | KMT2A (0.46) | SMN1; SMN2GAAHTTTSHRALDH1A1 | |
| SCHEMBL4038204 | 0.84 | EPHX2 (0.47) | ALDH1A1L3MBTL1KMT2AMEN1 | |
| SCHEMBL4041277 | 0.83 | KMT2A (0.41) | SMN1; SMN2GAAHTTTSHRALDH1A1 | |
| SCHEMBL4035567 | 0.83 | LMNA (0.48) | GAAHTTTSHRALDH1A1KMT2A | |
| SCHEMBL4032408 | 0.83 | ALDH1A1 (0.52) | MMP2SMN1; SMN2GAAHTTTSHR | |
| SCHEMBL4037894 | 0.83 | ALDH1A1 (0.54) | SMN1; SMN2HTTTSHRALDH1A1L3MBTL1 | |
| SCHEMBL4037611 | 0.83 | ALDH1A1 (0.53) | SMN1; SMN2GAATSHRALDH1A1KMT2A | |
| SCHEMBL4034055 | 0.82 | L3MBTL1 (0.45) | MMP13GAAHTTTSHRALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1730144-B1 | SUBSTITUTED 1,4,8-TRIAZASPIRO¬4.5 DECAN-2-ONE COMPOUNDS | GRUENENTHAL GMBH (DE) | 2009-06-10 | — | — | EP | claimed |