Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 12/20 | 0.35 |
| ▸ | PREP | P48147 | 2/20 | 0.34 |
| ▸ | FAP | Q12884 | 2/20 | 0.34 |
| ▸ | MC4R | P32245 | 1/20 | 0.33 |
| ▸ | MC3R | P41968 | 1/20 | 0.33 |
| ▸ | MC1R | Q01726 | 1/20 | 0.33 |
| ▸ | CTSL | P07711 | 5/20 | 0.31 |
| ▸ | CTSS | P25774 | 5/20 | 0.31 |
| ▸ | CTSB | P07858 | 2/20 | 0.31 |
| ▸ | CTSV | O60911 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | CRHBP | P24387 | 1/20 | 0.30 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.30 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4048011 | 0.93 | CTSK (0.40) | CTSKCTSLCTSSCTSBCTSV | |
| SCHEMBL4044612 | 0.91 | PREP (0.33) | CTSKPREPFAPMC4RMC3R | |
| SCHEMBL4043984 | 0.90 | CTSK (0.39) | CTSKCTSLCTSSCTSBCTSV | |
| SCHEMBL4047535 | 0.89 | MC4R (0.38) | CTSKPREPFAPMC4RMC3R | |
| SCHEMBL4045685 | 0.88 | PREP (0.34) | CTSKPREPFAPMC4RMC3R | |
| SCHEMBL4043756 | 0.88 | CTSK (0.40) | CTSKPREPFAPMC4RMC3R | |
| SCHEMBL4042570 | 0.88 | CTSK (0.34) | CTSKPREPFAPMC4RMC3R | |
| SCHEMBL4045022 | 0.88 | CTSK (0.35) | CTSKPREPFAPCTSLCTSS | |
| SCHEMBL4039641 | 0.88 | CTSK (0.34) | CTSKPREPFAPP2RY12 | |
| SCHEMBL4047432 | 0.88 | ALDH1A1 (0.35) | CTSKPREPFAPCTSSALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1546150-B1 | PYRROLE DERIVATIVES AS INHIBITORS OF CYTEINE PROTEASES | AMURA THERAPEUTICS LTD (GB) | 2009-03-04 | — | — | EP | claimed |