Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MC4R | P32245 | 2/20 | 0.38 |
| ▸ | MC3R | P41968 | 2/20 | 0.38 |
| ▸ | MC1R | Q01726 | 2/20 | 0.38 |
| ▸ | CTSK | P43235 | 9/20 | 0.34 |
| ▸ | CCR1 | P32246 | 1/20 | 0.34 |
| ▸ | PREP | P48147 | 1/20 | 0.34 |
| ▸ | FAP | Q12884 | 1/20 | 0.34 |
| ▸ | F2 | P00734 | 1/20 | 0.34 |
| ▸ | CTSL | P07711 | 6/20 | 0.33 |
| ▸ | CTSS | P25774 | 6/20 | 0.33 |
| ▸ | CTSB | P07858 | 3/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.31 |
| ▸ | CTSV | O60911 | 1/20 | 0.31 |
| ▸ | FAAH | O00519 | 1/20 | 0.31 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.31 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4043678 | 0.95 | ALDH1A1 (0.38) | MC4RMC3RMC1RCTSKPREP | |
| SCHEMBL4043256 | 0.92 | CTSK (0.41) | MC4RMC3RMC1RCTSKCTSL | |
| SCHEMBL4052303 | 0.92 | CTSK (0.35) | MC4RMC3RMC1RCTSKPREP | |
| SCHEMBL4046061 | 0.90 | LMNA (0.36) | PREPFAPSMN1; SMN2 | |
| SCHEMBL4044230 | 0.89 | CTSL (0.40) | CTSKCTSLCTSSCTSBCTSV | |
| SCHEMBL4052232 | 0.89 | CTSK (0.38) | MC4RMC3RMC1RCTSKPREP | |
| SCHEMBL4043203 | 0.89 | CTSK (0.35) | MC4RMC3RMC1RCTSKPREP | |
| SCHEMBL4044691 | 0.89 | PREP (0.35) | MC4RMC3RMC1RCTSKPREP | |
| SCHEMBL4041785 | 0.88 | PREP (0.35) | MC4RMC3RMC1RCTSKPREP | |
| SCHEMBL4049192 | 0.88 | CTSK (0.37) | MC4RMC3RMC1RCTSKPREP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1546150-B1 | PYRROLE DERIVATIVES AS INHIBITORS OF CYTEINE PROTEASES | AMURA THERAPEUTICS LTD (GB) | 2009-03-04 | — | — | EP | claimed |