Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSL | P07711 | 3/20 | 0.41 |
| ▸ | CTSS | P25774 | 3/20 | 0.41 |
| ▸ | CTSV | O60911 | 2/20 | 0.41 |
| ▸ | GPR132 | Q9UNW8 | 1/20 | 0.35 |
| ▸ | ELANE | P08246 | 1/20 | 0.32 |
| ▸ | HTRA1 | Q92743 | 2/20 | 0.32 |
| ▸ | CTSK | P43235 | 4/20 | 0.32 |
| ▸ | F12 | P00748 | 2/20 | 0.31 |
| ▸ | FPR2 | P25090 | 1/20 | 0.31 |
| ▸ | PREP | P48147 | 1/20 | 0.31 |
| ▸ | FAP | Q12884 | 1/20 | 0.31 |
| ▸ | CPB2 | Q96IY4 | 1/20 | 0.31 |
| ▸ | F2RL1 | P55085 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4043817 | 0.90 | CTSL (0.39) | CTSLCTSSCTSVGPR132HTRA1 | |
| SCHEMBL4045591 | 0.90 | CTSK (0.41) | CTSLCTSSELANECTSKPREP | |
| SCHEMBL4047790 | 0.89 | CTSK (0.36) | CTSLCTSSELANECTSKPREP | |
| SCHEMBL4051473 | 0.89 | CTSK (0.34) | GPR132ELANECTSKPREPFAP | |
| SCHEMBL4047756 | 0.88 | CTSL (0.38) | CTSLCTSSCTSVGPR132HTRA1 | |
| SCHEMBL4051046 | 0.88 | CTSV (0.39) | CTSLCTSSCTSVGPR132ELANE | |
| SCHEMBL4050085 | 0.87 | CTSS (0.40) | CTSLCTSSCTSVHTRA1CTSK | |
| SCHEMBL4047616 | 0.84 | CTSL (0.46) | CTSLCTSSCTSVCTSK | |
| SCHEMBL4048072 | 0.83 | CTSV (0.39) | CTSLCTSSCTSVGPR132HTRA1 | |
| SCHEMBL4044772 | 0.83 | CTSV (0.39) | CTSLCTSSCTSVGPR132HTRA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1546150-B1 | PYRROLE DERIVATIVES AS INHIBITORS OF CYTEINE PROTEASES | AMURA THERAPEUTICS LTD (GB) | 2009-03-04 | — | — | EP | claimed |