Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSV | O60911 | 2/20 | 0.39 |
| ▸ | CTSL | P07711 | 2/20 | 0.39 |
| ▸ | CTSS | P25774 | 2/20 | 0.39 |
| ▸ | GPR132 | Q9UNW8 | 1/20 | 0.35 |
| ▸ | F12 | P00748 | 2/20 | 0.33 |
| ▸ | ELANE | P08246 | 1/20 | 0.32 |
| ▸ | PREP | P48147 | 2/20 | 0.32 |
| ▸ | FAP | Q12884 | 1/20 | 0.32 |
| ▸ | HTRA1 | Q92743 | 2/20 | 0.32 |
| ▸ | CTSK | P43235 | 2/20 | 0.32 |
| ▸ | FPR2 | P25090 | 1/20 | 0.31 |
| ▸ | AVPR1B | P47901 | 1/20 | 0.31 |
| ▸ | CPB2 | Q96IY4 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | PSMB11 | A5LHX3 | 1/20 | 0.31 |
| ▸ | PSMA7 | O14818 | 1/20 | 0.31 |
| ▸ | PSMB1 | P20618 | 1/20 | 0.31 |
| ▸ | PSMA1 | P25786 | 1/20 | 0.31 |
| ▸ | PSMA2 | P25787 | 1/20 | 0.31 |
| ▸ | PSMA3 | P25788 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4047118 | 0.90 | CTSK (0.41) | CTSLCTSSELANEPREPFAP | |
| SCHEMBL4046543 | 0.90 | KCNQ1 (0.38) | CTSVCTSLCTSSGPR132F12 | |
| SCHEMBL4045044 | 0.89 | CTSK (0.36) | ELANEPREPFAPCTSKAVPR1B | |
| SCHEMBL4045553 | 0.89 | CTSK (0.34) | GPR132ELANEPREPFAPCTSK | |
| SCHEMBL4045926 | 0.88 | GPR132 (0.36) | CTSVCTSLCTSSGPR132HTRA1 | |
| SCHEMBL4043551 | 0.88 | CTSL (0.41) | CTSVCTSLCTSSGPR132F12 | |
| SCHEMBL4041994 | 0.88 | CTSS (0.39) | CTSVCTSLCTSSF12HTRA1 | |
| SCHEMBL4048072 | 0.86 | CTSV (0.39) | CTSVCTSLCTSSGPR132F12 | |
| SCHEMBL4042447 | 0.84 | CTSL (0.43) | CTSVCTSLCTSSCTSK | |
| SCHEMBL4041667 | 0.83 | HTRA1 (0.38) | CTSVCTSLCTSSGPR132F12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1546150-B1 | PYRROLE DERIVATIVES AS INHIBITORS OF CYTEINE PROTEASES | AMURA THERAPEUTICS LTD (GB) | 2009-03-04 | — | — | EP | claimed |