Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 1/20 | 0.47 |
| ▸ | MAOB | P27338 | 1/20 | 0.47 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | CPA1 | P15085 | 1/20 | 0.40 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | PPARD | Q03181 | 1/20 | 0.38 |
| ▸ | PPARA | Q07869 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | PYCR1 | P32322 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4039591 | 0.83 | SLC6A2 (0.47) | MAOBKMT2APPARA | |
| SCHEMBL4040112 | 0.80 | LDHA (0.56) | HTTALDH1A1PPARACYP2D6CYP2C19 | |
| SCHEMBL4035809 | 0.79 | MAOA (0.41) | MAOAMAOBTRPA1HPGDALDH1A1 | |
| SCHEMBL16474009 | 0.79 | TRPA1 (0.50) | TRPA1HPGDHTTCPA1FFAR1 | |
| SCHEMBL6005381 | 0.78 | PPARA (0.53) | TRPA1HPGDLMNACPA1KMT2A | |
| SCHEMBL1515224 | 0.78 | PPARA (0.53) | TRPA1HPGDLMNACPA1KMT2A | |
| SCHEMBL15012163 | 0.78 | TRPA1 (0.53) | MAOAMAOBTRPA1HPGDHTT | |
| SCHEMBL21400125 | 0.77 | TRPA1 (0.52) | MAOAMAOBTRPA1HPGDHTT | |
| SCHEMBL15881064 | 0.77 | TRPA1 (0.52) | TRPA1HPGDHTTCPA1KMT2A | |
| SCHEMBL22098557 | 0.75 | LMNA (0.35) | MAOAMAOBLMNAPPARA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2038279-A2 | SUBSTITUTED PYRAZOLO [1,5- ALPHA] PYRIDINE COMPOUNDS AND THEIR METHODS OF USE | Avigen, Inc. (US) | 2009-03-25 | — | — | EP | disclosed |
| WO-2007146087-A2 | SUBSTITUTED PYRAZOLO [1,5-α] PYRIDINE COMPOUNDS AND THEIR METHODS OF USE | AVIGEN, INC. (US) | 2007-12-21 | — | — | WO | disclosed |