Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 | P07550 | 7/20 | 0.39 |
| ▸ | ADRB1 | P08588 | 6/20 | 0.39 |
| ▸ | ADRB3 | P13945 | 6/20 | 0.39 |
| ▸ | ABCB1 | P08183 | 5/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.39 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.39 |
| ▸ | ABCC9 | O60706 | 1/20 | 0.39 |
| ▸ | KCNK2 | O95069 | 1/20 | 0.39 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.39 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | HTR2C | P28335 | 1/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.39 |
| ▸ | HTR2B | P41595 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4037688 | 0.83 | KDM4E (0.46) | ADRB2ADRB1ADRB3SMN1; SMN2KMT2A | |
| SCHEMBL4044662 | 0.82 | ABCB1 (0.39) | ADRB2ADRB1ADRB3ABCB1LMNA | |
| SCHEMBL4042381 | 0.81 | ADRB2 (0.59) | ADRB2ADRB1ADRB3LMNACYP2D6 | |
| SCHEMBL4041765 | 0.81 | ADRB3 (0.46) | ADRB2ADRB1ADRB3CYP2D6KMT2A | |
| SCHEMBL4045617 | 0.78 | ADRB1 (0.36) | ADRB2ADRB1ADRB3ABCB1LMNA | |
| SCHEMBL4049170 | 0.76 | MPO (0.39) | ADRB2ADRB1ADRB3ABCB1LMNA | |
| SCHEMBL4038893 | 0.75 | SLC6A5 (0.39) | ADRB2ADRB1ADRB3ABCB1LMNA | |
| SCHEMBL4048154 | 0.74 | BCHE (0.43) | KMT2AMEN1 | |
| SCHEMBL4041577 | 0.72 | ALDH1A1 (0.38) | ADRA2CKMT2AMEN1METAP2METAP1 | |
| SCHEMBL4036513 | 0.71 | RPS6KB1 (0.40) | ADRB2ADRB1ADRB3ABCB1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2051967-A1 | BENZIMIDAZOLE DERIVATIVES USEFUL IN TREATMENT OF VALLINOID RECEPTOR TRPV1 RELATED DISORDERS | AstraZeneca AB (SE) | 2009-04-29 | — | — | EP | claimed |
| WO-2008018827-A1 | BENZIMIDAZOLE DERIVATIVES USEFUL IN TREATMENT OF VALLINOID RECEPTOR TRPV1 RELATED DISORDERS | ASTRAZENECA AB (SE) | 2008-02-14 | — | — | WO | claimed |