Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSL | P07711 | 2/20 | 0.38 |
| ▸ | CTSS | P25774 | 2/20 | 0.38 |
| ▸ | CTSK | P43235 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | HTT | P42858 | 2/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | FAAH | O00519 | 1/20 | 0.32 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | RECQL | P46063 | 1/20 | 0.31 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.31 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.31 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.31 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | NPC1 | O15118 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4044049 | 0.89 | CTSL (0.33) | CTSLCTSSCTSKLMNAGAA | |
| SCHEMBL6238275 | 0.88 | CTSL (0.40) | CTSLCTSSCTSKALDH1A1HTT | |
| SCHEMBL4041595 | 0.86 | CTSK (0.42) | CTSLCTSSCTSK | |
| SCHEMBL4042694 | 0.84 | CTSL (0.34) | CTSLCTSSCTSKALDH1A1HSD17B10 | |
| SCHEMBL4041874 | 0.83 | CHRNB2 (0.37) | HTTLMNAGAATSHRMEN1 | |
| SCHEMBL4045681 | 0.81 | LMNA (0.36) | CTSLCTSSCTSKALDH1A1HTT | |
| SCHEMBL4047235 | 0.80 | CTSL (0.36) | CTSLCTSSCTSKALDH1A1HSD17B10 | |
| SCHEMBL4041529 | 0.80 | CTSK (0.47) | CTSLCTSSCTSKALDH1A1HSD17B10 | |
| SCHEMBL4042558 | 0.80 | CTSK (0.39) | CTSLCTSSCTSKALDH1A1HTT | |
| SCHEMBL4050441 | 0.80 | CTSK (0.39) | CTSLCTSSCTSKALDH1A1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1546150-B1 | PYRROLE DERIVATIVES AS INHIBITORS OF CYTEINE PROTEASES | AMURA THERAPEUTICS LTD (GB) | 2009-03-04 | — | — | EP | claimed |