Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 4/20 | 0.39 |
| ▸ | PREP | P48147 | 5/20 | 0.38 |
| ▸ | FAP | Q12884 | 5/20 | 0.38 |
| ▸ | CTSL | P07711 | 2/20 | 0.36 |
| ▸ | CTSS | P25774 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | TGM2 | P21980 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4041529 | 0.92 | CTSK (0.47) | CTSKCTSLCTSSALDH1A1HSD17B10 | |
| SCHEMBL4042558 | 0.92 | CTSK (0.39) | CTSKPREPFAPCTSLCTSS | |
| SCHEMBL4040090 | 0.89 | PREP (0.36) | CTSKPREPFAPCTSLCTSS | |
| SCHEMBL4050878 | 0.89 | CTSK (0.38) | CTSKPREPFAPCTSLCTSS | |
| SCHEMBL4043247 | 0.86 | CTSK (0.39) | CTSKPREPFAPCTSLCTSS | |
| SCHEMBL4045830 | 0.85 | CTSK (0.39) | CTSKPREPFAPCTSLCTSS | |
| SCHEMBL4040800 | 0.85 | PREP (0.36) | CTSKPREPFAPCTSLCTSS | |
| SCHEMBL4040431 | 0.84 | CHRNB2 (0.37) | CTSKPREPFAPHTTSMN1; SMN2 | |
| SCHEMBL4044465 | 0.83 | CTSK (0.43) | CTSKPREPFAPCTSLCTSS | |
| SCHEMBL4045843 | 0.83 | CTSK (0.43) | CTSKPREPFAPCTSLCTSS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1546150-B1 | PYRROLE DERIVATIVES AS INHIBITORS OF CYTEINE PROTEASES | AMURA THERAPEUTICS LTD (GB) | 2009-03-04 | — | — | EP | claimed |