Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | BCAT2 | O15382 | 1/20 | 0.41 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.38 |
| ▸ | IKBKB | O14920 | 1/20 | 0.38 |
| ▸ | CASP3 | P42574 | 2/20 | 0.38 |
| ▸ | SENP8 | Q96LD8 | 2/20 | 0.38 |
| ▸ | SENP7 | Q9BQF6 | 2/20 | 0.38 |
| ▸ | SENP6 | Q9GZR1 | 2/20 | 0.38 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.37 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | LTB4R | Q15722 | 2/20 | 0.36 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | TYR | P14679 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15286612 | 0.95 | GPR35 (0.43) | PKMBCAT2GPR35ALDH1A1LTB4R | |
| SCHEMBL6928575 | 0.93 | GPR35 (0.46) | PKMGPR35LTB4RCYSLTR2CYSLTR1 | |
| SCHEMBL30412970 | 0.92 | GPR35 (0.45) | PKMGPR35LTB4RCYSLTR2CYSLTR1 | |
| SCHEMBL3077087 | 0.89 | PKM (0.43) | PKMBCAT2IKBKBMAPK8MAPK10 | |
| SCHEMBL27675976 | 0.84 | GPR35 (0.49) | GPR35ALDH1A1LTB4RHPGDHSD17B10 | |
| SCHEMBL18599007 | 0.84 | TYR (0.41) | GPR35CASP3SENP8SENP7SENP6 | |
| SCHEMBL2279587 | 0.83 | BCAT2 (0.47) | PKMBCAT2IKBKBMAPK8MAPK10 | |
| SCHEMBL30230239 | 0.83 | BCAT2 (0.41) | PKMBCAT2MAPK8MAPK10ALDH1A1 | |
| SCHEMBL1935630 | 0.82 | LTB4R (0.40) | PKMBCAT2IKBKBMAPK8MAPK10 | |
| Formamide SCHEMBL27759308 | 0.81 | GPR35 (0.44) | GPR35LTB4RGABRPGABRDGABRA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2038289-A2 | THIENO-[2,3-D]PYRIMIDINE AND THIENO-PYRIDAZINE COMPOUNDS AND METHODS OF USE | Amgen Inc. (US) | 2009-03-25 | — | — | EP | disclosed |
| WO-2007124181-A2 | THIENO-[2,3-D]PYRIMIDINE AND THIENO-PYRIDAZINE COMPOUNDS AND METHODS OF USE | AMGEN INC. (US) | 2007-11-01 | — | — | WO | disclosed |