Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGA4 | P13612 | 1/20 | 0.36 |
| ▸ | ITGB7 | P26010 | 1/20 | 0.36 |
| ▸ | FNTA | P49354 | 1/20 | 0.35 |
| ▸ | FNTB | P49356 | 1/20 | 0.35 |
| ▸ | ELANE | P08246 | 1/20 | 0.34 |
| ▸ | CTSK | P43235 | 3/20 | 0.34 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.34 |
| ▸ | GPR132 | Q9UNW8 | 1/20 | 0.33 |
| ▸ | ACE | P12821 | 2/20 | 0.33 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.33 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.33 |
| ▸ | PRCP | P42785 | 1/20 | 0.33 |
| ▸ | BCL2 | P10415 | 1/20 | 0.33 |
| ▸ | CTSL | P07711 | 1/20 | 0.32 |
| ▸ | CTSB | P07858 | 1/20 | 0.32 |
| ▸ | CTSS | P25774 | 1/20 | 0.32 |
| ▸ | XIAP | P98170 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4049324 | 0.94 | MC4R (0.37) | ITGA4ITGB7ELANECTSKP2RX7 | |
| SCHEMBL4051785 | 0.94 | ITGA4 (0.39) | ITGA4ITGB7ELANECTSKHDAC8 | |
| SCHEMBL4046932 | 0.93 | GPR132 (0.35) | ITGA4ITGB7FNTAFNTBELANE | |
| SCHEMBL4041003 | 0.90 | CTSL (0.39) | CTSKCTSLCTSBCTSS | |
| SCHEMBL4045311 | 0.89 | CTSK (0.43) | ELANECTSKCTSLCTSBCTSS | |
| SCHEMBL4047615 | 0.88 | CTSB (0.38) | CTSKACE2GPR132ACEBCL2 | |
| SCHEMBL4043139 | 0.88 | ELANE (0.37) | ITGA4ITGB7ELANECTSK | |
| SCHEMBL4045047 | 0.88 | CTSL (0.37) | ITGA4ITGB7FNTAFNTBCTSK | |
| SCHEMBL4044814 | 0.88 | FNTA (0.35) | ITGA4ITGB7FNTAFNTBCTSK | |
| SCHEMBL4048142 | 0.87 | GAA (0.36) | ITGA4ITGB7FNTAFNTBCTSK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1546150-B1 | PYRROLE DERIVATIVES AS INHIBITORS OF CYTEINE PROTEASES | AMURA THERAPEUTICS LTD (GB) | 2009-03-04 | — | — | EP | claimed |