Altanserin

Altanserin

SCHEMBL404849

O=C(c1ccc(F)cc1)C1CCN(CCn2c(=S)[nH]c3ccccc3c2=O)CC1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HTR2A P28223 4/20 1.00
CYP3A4 P08684 3/20 1.00
HPGD P15428 3/20 1.00
CYP2D6 P10635 3/20 1.00
HTR2C P28335 3/20 1.00
CYP1A2 P05177 2/20 1.00
HTR1A P08908 2/20 1.00
CYP2C9 P11712 2/20 1.00
DRD2 P14416 2/20 1.00
TSHR P16473 2/20 1.00
ALDH1A1 P00352 3/20 0.82
CYP2C19 P33261 2/20 0.82
LMNA P02545 2/20 0.82
MAPT P10636 2/20 0.82
KMT2A Q03164 2/20 0.82
KCNH2 Q12809 2/20 0.82
MEN1 O00255 1/20 0.82
ADRA2B P18089 1/20 0.82
ADRA2C P18825 1/20 0.82
DRD1 P21728 1/20 0.82

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Altanserin SCHEMBL30136524 1.00 HTR2A (1.00) HTR2ACYP3A4HPGDCYP2D6HTR2C
Altanserin SCHEMBL12629110 1.00 HTR2A (1.00) HTR2ACYP3A4HPGDCYP2D6HTR2C
Altanserin SCHEMBL30136526 1.00 HTR2A (1.00) HTR2ACYP3A4HPGDCYP2D6HTR2C
Altanserin SCHEMBL15662949 0.99 HTR2A (1.00) HTR2ACYP3A4HPGDCYP2D6HTR2C
SCHEMBL11015897 0.94 HTR2A (0.89) HTR2ACYP3A4HPGDCYP2D6HTR2C
Altanserin SCHEMBL124036 0.94 HTR2A (0.88) HTR2ACYP3A4HPGDCYP2D6HTR2C
Altanserin SCHEMBL124037 0.94 HTR2A (0.88) HTR2ACYP3A4HPGDCYP2D6HTR2C
SCHEMBL21104614 0.90 HTR2A (0.82) HTR2ACYP3A4HPGDCYP2D6HTR2C
SCHEMBL14544003 0.90 HTR2A (0.82) HTR2ACYP3A4HPGDCYP2D6HTR2C
Ketanserin SCHEMBL29361038 0.90 HTR2A (1.00) HTR2ACYP3A4HPGDCYP2D6HTR2C

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 539 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4725483-A1 COMBINATION COMPRISING AT LEAST ONE 5-HT2A RECEPTOR ANTAGONIST AND AT LEAST ONE 5-HT3 RECEPTOR ANTAGONIST AND ITS MEDICAL USE Université de Bordeaux (FR) 2026-04-15 EP claimed
EP-4680244-A1 SEROTONIN 5HT2A RECEPTOR ANTAGONIST FOR USE IN TREATING SIDE EFFECTS RESULTING FORM MU OPIOID RECEPTOR AGONIST OVERDOSE Norwegian University Of Life Sciences (NO) 2026-01-21 EP claimed
US-12514937-B2 Methods for detecting CCR2 receptors WASHINGTON UNIVERSITY (US) 2026-01-06 US claimed
US-20260000641-A1 ISOTOPICALLY ENRICHED ANALOGS OF 5,6-METHYLENEDIOXY-2-AMINOINDANE (IMDAI) TERRAN BIOSCIENCES INC (US) 2026-01-01 US claimed
WO-2025264860-A2 METHODS OF TREATING POST-COVID AIRWAY DISEASE YALE UNIVERSITY (US) 2025-12-26 WO claimed
WO-2025226286-A1 SYSTEMS AND METHODS FOR SIMULTANEOUS IMAGING OF MULTIPLE POSITRON EMISSION TOMOGRAPHY (PET) TRACERS MULTIF UNCTIONAL IMAGING LLC (US) 2025-10-30 WO claimed
US-20250329024-A1 SYSTEMS AND METHODS FOR SIMULTANEOUS IMAGING OF MULTIPLE POSITRON EMISSION TOMOGRAPHY (PET) TRACERS MultiFunctional Imaging LLC (US) 2025-10-23 US claimed
US-20250295611-A1 METHODS OF TREATING 5HT2A RECEPTOR-MEDIATED CONDITIONS TESSELLATE THERAPEUTICS INC (US) 2025-09-25 US claimed
EP-4547250-A1 METHODS AND COMPOSITIONS RELATING TO CONTROLLING PSYCHEDELIC EFFECTS WITH SEROTONIN RECEPTOR MODULATORS Terran Biosciences Inc. (US) 2025-05-07 EP claimed
US-20250136548-A1 FUNCTIONALIZED ALKYLAMINES TERRAN BIOSCIENCES INC (US) 2025-05-01 US claimed
US-20100226943-A1 SURFACE TOPOGRAPHIES FOR NON-TOXIC BIOADHESION CONTROL UNIVERSITY OF FLORIDA (US) 2010-09-09 US claimed
CN-101677971-A The combination of 5-HT2A inverse agonist and antagonist and antipsychotic drug ACADIA PHARM INC 2010-03-24 CN claimed
EP-2134330-A2 COMBINATIONS OF 5-HT2A INVERSE AGONISTS AND ANTAGONISTS WITH ANTIPSYCHOTICS Acadia Pharmaceuticals Inc. (US) 2009-12-23 EP claimed
WO-2009108798-A1 METHOD FOR TREATING PAIN SYNDROME AND OTHER DISORDERS VM DISCOVERY INC. (US) 2009-09-03 WO claimed
US-20090053329-A1 COMBINATIONS OF 5-HT2A INVERSE AGONISTS AND ANTAGONISTS WITH ANTIPSYCHOTICS ACADIA PHARMACEUTICALS, INC. (US) 2009-02-26 US claimed
CN-101330905-A Freeze-drying process and products obtained thereby SCIDOSE LLC (US) 2008-12-24 CN claimed
WO-2008116024-A2 COMBINATIONS OF 5-HT2A INVERSE AGONISTS AND ANTAGONISTS WITH ANTIPSYCHOTICS ACADIA PHARMACEUTICALS INC. (US) 2008-09-25 WO claimed
EP-1954244-A1 LYOPHILIZATION PROCESS AND PRODUCTS OBTAINED THEREBY Scidose, Llc (US) 2008-08-13 EP claimed
WO-2007061529-A1 LYOPHILIZATION PROCESS AND PRODUCTS OBTAINED THEREBY SCIDOSE LLC. (US) 2007-05-31 WO claimed
US-20070116729-A1 Lyophilization process and products obtained thereby SCIDOSE LLC 2007-05-24 US claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260000641-A1 ISOTOPICALLY ENRICHED ANALOGS OF 5,6-METHYLENEDIOXY-2-AMINOINDANE (IMDAI) DRD2, HTR1D, DRD1 HTR2A 7/4885CYP3A4 2054/4885HPGD 1740/4885
US-20250295611-A1 METHODS OF TREATING 5HT2A RECEPTOR-MEDIATED CONDITIONS HTR2A, HTR5A, HTR6 HTR2A 1/4885CYP3A4 1995/4885HPGD 965/4885
US-20250136548-A1 FUNCTIONALIZED ALKYLAMINES BDNF, HTR2A, NTRK2 HTR2A 2/4885CYP3A4 4707/4885HPGD 2941/4885
US-20090053329-A1 COMBINATIONS OF 5-HT2A INVERSE AGONISTS AND ANTAGONISTS WITH ANTIPSYCHOTICS HTR2A, HTR3A, HTR1A HTR2A 1/4885CYP3A4 809/4885HPGD 2287/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.