Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 1/20 | 0.41 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.41 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | IDO1 | P14902 | 1/20 | 0.36 |
| ▸ | TACR2 | P21452 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | C3AR1 | Q16581 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | NAMPT | P43490 | 2/20 | 0.33 |
| ▸ | KLK7 | P49862 | 1/20 | 0.32 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4043466 | 0.88 | CHRNB2 (0.40) | CHRNB2CHRNA7CHRNA4ALDH1A1HPGD | |
| SCHEMBL4045182 | 0.85 | KCNQ1 (0.37) | CHRNB2CHRNA7CHRNA4ALDH1A1HPGD | |
| SCHEMBL4046100 | 0.84 | KLK7 (0.35) | CHRNB2CHRNA7CHRNA4ALDH1A1HPGD | |
| SCHEMBL4047235 | 0.83 | CTSL (0.36) | ALDH1A1HPGDTACR2KDM4EGAA | |
| SCHEMBL4047073 | 0.83 | CHRNB2 (0.43) | CHRNB2CHRNA7CHRNA4ALDH1A1HPGD | |
| SCHEMBL4043880 | 0.82 | CHRNB2 (0.41) | CHRNB2CHRNA7CHRNA4ALDH1A1HPGD | |
| SCHEMBL4044034 | 0.82 | CHRNB2 (0.41) | CHRNB2CHRNA7CHRNA4ALDH1A1HPGD | |
| SCHEMBL4041874 | 0.81 | CHRNB2 (0.37) | CHRNB2CHRNA7CHRNA4MAPTGAA | |
| SCHEMBL4044847 | 0.80 | CHRNB2 (0.39) | CHRNB2CHRNA7CHRNA4ALDH1A1HPGD | |
| SCHEMBL4050955 | 0.80 | CTSK (0.37) | HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1546150-B1 | PYRROLE DERIVATIVES AS INHIBITORS OF CYTEINE PROTEASES | AMURA THERAPEUTICS LTD (GB) | 2009-03-04 | — | — | EP | claimed |