Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TPH1 | P17752 | 2/20 | 0.49 |
| ▸ | VCP | P55072 | 2/20 | 0.47 |
| ▸ | CKS1B | P61024 | 1/20 | 0.44 |
| ▸ | SKP1 | P63208 | 1/20 | 0.44 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.44 |
| ▸ | GPR119 | Q8TDV5 | 6/20 | 0.42 |
| ▸ | JAK3 | P52333 | 2/20 | 0.42 |
| ▸ | JAK2 | O60674 | 1/20 | 0.42 |
| ▸ | JAK1 | P23458 | 1/20 | 0.42 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.41 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.40 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13690743 | 0.89 | VCP (0.48) | TPH1VCPCKS1BSKP1SKP2 | |
| SCHEMBL4562339 | 0.88 | GPR119 (0.49) | TPH1VCPGPR119TSHRCYP3A4 | |
| SCHEMBL3978507 | 0.88 | USP30 (0.47) | VCPCKS1BSKP1SKP2GPR119 | |
| SCHEMBL4056338 | 0.88 | TPH1 (0.46) | TPH1VCPCKS1BSKP1SKP2 | |
| SCHEMBL4053708 | 0.87 | NPY2R (0.48) | TPH1VCPCKS1BSKP1SKP2 | |
| SCHEMBL13690387 | 0.87 | GPR119 (0.59) | GPR119 | |
| SCHEMBL4055884 | 0.87 | GPR119 (0.59) | TPH1GPR119GRIN2B | |
| SCHEMBL4050644 | 0.87 | TPH1 (0.50) | TPH1KDM4ETSHRHSD17B10CYP3A4 | |
| SCHEMBL3983111 | 0.86 | VCP (0.47) | VCPCKS1BSKP1SKP2GPR119 | |
| SCHEMBL4565563 | 0.86 | GRIN2B (0.62) | CYP3A4CYP2D6CYP2C9GRIN2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009106561-A1 | PYRAZINE COMPOUNDS FOR TREATING GPR119 RELATED DISORDERS | BIOVITRUM AB (PUBL) (SE) | 2009-09-03 | — | — | WO | disclosed |